ReviewNeurobiology of stress2019
Stress, sensitive periods, and substance abuse.
Review in Neurobiology of stress, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Premature release of action sequences in adolescent male rats.Frontiers in behavioral neuroscience · 2026Article
- Discrimination Distress and Current Combustible and Non-combustible Tobacco Product Use Among US Youth, 2023.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Pathogenesis of HIV-associated depression: contributing factors and underlying mechanisms.Frontiers in psychiatry · 2025Review
- Machine-learning detection of stress severity expressed on a continuous scale using acoustic, verbal, visual, and physiological data: lessons learned.Frontiers in psychiatry · 2025Article
- Neurobiological intersections of stress and substance use disorders.Frontiers in neuroscience · 2025Review
- Male and female behavioral variability and morphine response in C57BL/6J, DBA/2J, and their BXD progeny following chronic stress exposure.Scientific reports · 2024Article
- Success4Life Youth Empowerment Pilot for Promoting Well-Being in University Students: A Qualitative Study.Cureus · 2024Article
- Internalizing Pathways to Adolescent Substance Use from Adverse Childhood Experiences.International journal of environmental research and public health · 2024Article
- Sex differences in the roles of nicotine use and puberty on youth C-reactive protein levels: Effects above and beyond adversity.Brain, behavior, & immunity - health · 2024Article
- Intersection of adverse childhood experiences, suicide and overdose prevention.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2024Review
- Affective-Sexual Behaviors in Youth: Analysis of a Public Health Survey in the School Setting.Healthcare (Basel, Switzerland) · 2024Article
- Could school programs based on social-emotional learning prevent substance abuse among adolescents?World journal of psychiatry · 2024Article
- Individual and Community level Developmental Adversities: Associations with Marijuana and Alcohol Use in Late-Adolescents and Young Adults.Journal of youth and adolescence · 2024Article
- Childhood adversity and psychopathology: the dimensions of timing, type and chronicity in a population-based sample of high-risk adolescents.Child and adolescent psychiatry and mental health · 2024Article
- Perceived racism and discrimination and youth substance use in the United States - Intersections with sex and ethnicity.Preventive medicine · 2024Article
- Climate Change and Substance-Use Behaviors: A Risk-Pathways Framework.Perspectives on psychological science : a journal of the Association for Psychological Science · 2023Article
- Sex- and exposure age-dependent effects of adolescent stress on ventral tegmental area dopamine system and its afferent regulators.Molecular psychiatry · 2023Article
- Cannabis in Adolescence: Lasting Cognitive Alterations and Underlying Mechanisms.Cannabis and cannabinoid research · 2023Review
- Adverse childhood experiences and adolescent drug use in the UK: The moderating role of socioeconomic position and ethnicity.SSM - population health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Research on the inter-relationship between drug abuse and social stress has primarily focused on the role of stress exposure during adulthood and more recently, adolescence. Adolescence is a time of heightened reward sensitivity, but it is also a time when earlier life experiences are expressed. Exposure to stress early in postnatal life is associated with an accelerated age of onset for drug use. Lifelong addiction is significantly greater if drug use is initiated during early adolescence. Understanding how developmental changes following stress exposure interact with sensitive periods to unfold over the course of maturation is integral to reducing their later impact on substance use. Arousal levels, gender/sex, inflammation, and the timing of stress exposure play a role in the vulnerability of these circuits. The current review focuses on how early postnatal stress impacts brain development during a sensitive period to increase externalizing and internalizing behaviors in adolescence that include social interactions (aggression; sexual activity), working memory impairment, and depression. How stress effects the developmental trajectories of brain circuits that are associated with addiction are discussed for both clinical and preclinical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.