Evidence map›Paper›PMID 30568999›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2019

Circulating inflammatory biomarkers are related to cerebrovascular disease in older adults.

Yian Gu, Jose Gutierrez, Irene B Meier, Vanessa A Guzman, Jennifer J Manly, Nicole Schupf, Adam M Brickman, Richard Mayeux

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
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  7. Decoding neurovascular signatures: advanced imaging insights in DADA2-Related Cerebral Microangiopathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yian GuTaub Institute for Research in Alzheimer's Disease and the Aging Brain (Y.G., I.B.M., V.A.G., J.J.M., N.S., A.M.B., R.M.), Columbia University; Department of Neurology (Y.G., J.G., J.J.M., N.S., A.M.B., R.M.), Columbia University and the New York Presbyterian Hospital; Department of Epidemiology (Y.G., N.S., R.M.), Joseph P. Mailman School of Public Health, Columbia University; and the Gertrude H. Sergievsky Center (Y.G., J.J.M., A.M.B., R.M.), Columbia University, New York.
Jose GutierrezTaub Institute for Research in Alzheimer's Disease and the Aging Brain (Y.G., I.B.M., V.A.G., J.J.M., N.S., A.M.B., R.M.), Columbia University; Department of Neurology (Y.G., J.G., J.J.M., N.S., A.M.B., R.M.), Columbia University and the New York Presbyterian Hospital; Department of Epidemiology (Y.G., N.S., R.M.), Joseph P. Mailman School of Public Health, Columbia University; and the Gertrude H. Sergievsky Center (Y.G., J.J.M., A.M.B., R.M.), Columbia University, New York.
Irene B MeierTaub Institute for Research in Alzheimer's Disease and the Aging Brain (Y.G., I.B.M., V.A.G., J.J.M., N.S., A.M.B., R.M.), Columbia University; Department of Neurology (Y.G., J.G., J.J.M., N.S., A.M.B., R.M.), Columbia University and the New York Presbyterian Hospital; Department of Epidemiology (Y.G., N.S., R.M.), Joseph P. Mailman School of Public Health, Columbia University; and the Gertrude H. Sergievsky Center (Y.G., J.J.M., A.M.B., R.M.), Columbia University, New York.
Vanessa A GuzmanTaub Institute for Research in Alzheimer's Disease and the Aging Brain (Y.G., I.B.M., V.A.G., J.J.M., N.S., A.M.B., R.M.), Columbia University; Department of Neurology (Y.G., J.G., J.J.M., N.S., A.M.B., R.M.), Columbia University and the New York Presbyterian Hospital; Department of Epidemiology (Y.G., N.S., R.M.), Joseph P. Mailman School of Public Health, Columbia University; and the Gertrude H. Sergievsky Center (Y.G., J.J.M., A.M.B., R.M.), Columbia University, New York.
Jennifer J ManlyTaub Institute for Research in Alzheimer's Disease and the Aging Brain (Y.G., I.B.M., V.A.G., J.J.M., N.S., A.M.B., R.M.), Columbia University; Department of Neurology (Y.G., J.G., J.J.M., N.S., A.M.B., R.M.), Columbia University and the New York Presbyterian Hospital; Department of Epidemiology (Y.G., N.S., R.M.), Joseph P. Mailman School of Public Health, Columbia University; and the Gertrude H. Sergievsky Center (Y.G., J.J.M., A.M.B., R.M.), Columbia University, New York.
Nicole SchupfTaub Institute for Research in Alzheimer's Disease and the Aging Brain (Y.G., I.B.M., V.A.G., J.J.M., N.S., A.M.B., R.M.), Columbia University; Department of Neurology (Y.G., J.G., J.J.M., N.S., A.M.B., R.M.), Columbia University and the New York Presbyterian Hospital; Department of Epidemiology (Y.G., N.S., R.M.), Joseph P. Mailman School of Public Health, Columbia University; and the Gertrude H. Sergievsky Center (Y.G., J.J.M., A.M.B., R.M.), Columbia University, New York.
Adam M BrickmanTaub Institute for Research in Alzheimer's Disease and the Aging Brain (Y.G., I.B.M., V.A.G., J.J.M., N.S., A.M.B., R.M.), Columbia University; Department of Neurology (Y.G., J.G., J.J.M., N.S., A.M.B., R.M.), Columbia University and the New York Presbyterian Hospital; Department of Epidemiology (Y.G., N.S., R.M.), Joseph P. Mailman School of Public Health, Columbia University; and the Gertrude H. Sergievsky Center (Y.G., J.J.M., A.M.B., R.M.), Columbia University, New York.
Richard MayeuxTaub Institute for Research in Alzheimer's Disease and the Aging Brain (Y.G., I.B.M., V.A.G., J.J.M., N.S., A.M.B., R.M.), Columbia University; Department of Neurology (Y.G., J.G., J.J.M., N.S., A.M.B., R.M.), Columbia University and the New York Presbyterian Hospital; Department of Epidemiology (Y.G., N.S., R.M.), Joseph P. Mailman School of Public Health, Columbia University; and the Gertrude H. Sergievsky Center (Y.G., J.J.M., A.M.B., R.M.), Columbia University, New York.
Columbia University · USNewYork–Presbyterian Hospital · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MAYEUX, RICHARD P · 1989 to 2008
$21.7M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
The role of inflammation in the association between diet and Alzheimer's diseaseR01AG059013 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GU, YIAN · 2019 to 2023
$3.7M
White matter hyperintensities in Aging and DementiaR01AG034189 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M · 2010 to 2014
$2.0M
White Matter Hyperintentisities in Aging and DementiaR56AG034189 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M · 2016 to 2016
$793k
Dietary Factors and Neuroimaging MarkersR00AG042483 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GU, YIAN · 2015 to 2017
$727k
Dietary Factors and Neuroimaging MarkersK99AG042483 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GU, YIAN · 2013 to 2014
$202k
NCATS NIH HHS UL1 TR001873NIA NIH HHS K99 AG042483NIA NIH HHS P01 AG007232NIA NIH HHS R00 AG042483NIA NIH HHS R01 AG034189NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG059013NIA NIH HHS R56 AG034189NIA NIH HHS RF1 AG054023
6 · The paper itself

Abstract

Objective: This investigation aimed at examining whether circulating inflammatory biomarkers C-reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin (ACT) were related to cerebrovascular disease (CVD) assessed by MRI. Methods: The study included nondemented elderly participants of a community-based, multiethnic cohort, who received baseline MRI scans and had CRP (n = 508), ACT (435), and IL6 (N = 357) measured by ELISA. Silent brain infarcts and white matter hyperintensities (WMH) were derived from all available MRI scans at baseline, approximately 4.4 years after blood sample collection for inflammatory biomarkers. Repeated assessments of infarcts and WMH, as well as microbleeds assessment, were performed at follow-up MRI visits around 4.5 years later. Cross-sectional and longitudinal relationship between inflammatory biomarkers and CVD were analyzed using appropriate logistic regression models, generalized linear models, or COX models. Results: After adjusting for age, sex, ethnicity, education, Conclusions: Among older adults, increased circulating inflammatory biomarkers were associated with the presence of infarcts and microbleeds, WMH burden, and progression of WMH.

Indexed as

AgedAged, 80 and overalpha 1-AntichymotrypsinBiomarkersCerebrovascular DisordersCohort StudiesC-Reactive ProteinDisease ProgressionFemaleHumansInflammationInflammation MediatorsInterleukin-6Malealpha 1-AntichymotrypsinBiomarkersC-Reactive ProteinInflammation MediatorsInterleukin-6

Identifiers

PMID30568999
PMCPMC6278856
OpenAlexW2900914266

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.