Evidence map›Paper›PMID 30568901›Full record

ArticleAfrican journal of laboratory medicine2018

Differential infectivity of gametocytes after artemisinin-based combination therapy of uncomplicated falciparum malaria.

Dinkorma T Ouologuem, Cheick O Kone, Bakary Fofana, Bakary Sidibe, Amadou H Togo, Demba Dembele, Sekou Toure, Sekou Koumare, Ousmane Toure, Issaka Sagara and 4 more

Open access · diamondAbstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in African journal of laboratory medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

0.5field-weighted citation impact, top 27% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

Comparative effect of artemether-lumefantrine and artesunate-amodiaquine on gametocyte clearance in children with uncomplicated Plasmodium falciparum malaria in Madagascar.Malaria journal · 2022
Trial
The Effect of Artemether-Lumefantrine Combined with a Single Dose of Primaquine onTropical medicine and infectious disease · 2026
Article
A NovelAntimicrobial agents and chemotherapy · 2022
Article
Challenges in the clinical development pathway for triple and multiple drug combinations in the treatment of uncomplicated falciparum malaria.Malaria journal · 2022
Article
Shifts in the clinical epidemiology of severe malaria after scaling up control strategies in Mali.Frontiers in neurology · 2022
Article
Antimicrobial resistance surveillance in Africa: Successes, gaps and a roadmap for the future.African journal of laboratory medicine · 2018
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Dinkorma T OuologuemMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0002-3955-9843

Cheick O KoneMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0003-2547-7078

Bakary FofanaMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0002-5632-6304

Bakary SidibeMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0003-4771-6738

Amadou H TogoMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0002-0718-8216

Demba DembeleMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0002-4460-2252

Sekou ToureMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0003-4383-2774

Sekou KoumareMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0002-4356-0601

Ousmane ToureMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0001-6134-7452

Issaka SagaraMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0002-8555-9983

Abdoulaye ToureMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0002-7581-9411

Adama DaoMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0002-2373-9604

Ogobara K DoumboMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID https://orcid.org/0000-0001-8445-9641

Abdoulaye A DjimdeMalaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.ORCID 0000-0003-0062-2283

University of Bamako · ML

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost malaria-endemic countries use artemisinin-based combination therapy (ACT) as their first-line treatment. ACTs are known to be highly effective on asexual stages of the malaria parasite. Malaria transmission and the spread of resistant parasites depend on the infectivity of gametocytes. The effect of the current ACT regimens on gametocyte infectivity is unclear.

objectivesThis study aimed to determine the infectivity of gametocytes to

methodsDuring a randomised controlled trial in Bougoula-Hameau, Mali, conducted from July 2005 to July 2007, volunteers with uncomplicated malaria were randomised to receive artemether-lumefantrine, artesunate-amodiaquine, or artesunate-sulfadoxine/pyrimethamine. Volunteers were followed for 28 days, and gametocyte carriage was assessed. Direct skin feeding assays were performed on gametocyte carriers before and after ACT administration.

resultsFollowing artemether-lumefantrine treatment, gametocyte carriage decreased steadily from Day 0 to Day 21 post-treatment initiation. In contrast, for the artesunate-amodiaquine and artesunate-sulfadoxine/pyrimethamine arms, gametocyte carriage increased on Day 3 and remained constant until Day 7 before decreasing afterward. Mosquito feeding assays showed that artemether-lumefantrine and artesunate-amodiaquine significantly increased gametocyte infectivity to

conclusionDifferent ACT regimens could lead to gametocyte populations with different capacity to infect the

Identifiers

PMID30568901

DOI10.4102/ajlm.v7i2.784

PMCPMC6295776

OpenAlexW2905261649

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.