Evidence map›Paper›PMID 30568855›Full record

ArticlePeerJ2018

Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in

Caroline Zutterling, Aibek Mursalimov, Ibtissam Talhaoui, Zhanat Koshenov, Zhiger Akishev, Amangeldy K Bissenbaev, Gerard Mazon, Nicolas E Geacintov, Didier Gasparutto, Regina Groisman and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

Caroline ZutterlingGroupe «Réparation de l'ADN», Equipe Labellisée par la Ligue Nationale Contre le Cancer, CNRS UMR8200, Université Paris-Sud, Gustave Roussy Cancer Campus, Villejuif, France.
Aibek MursalimovNational Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Ibtissam TalhaouiCNRS UMR 8200-Laboratoire «Stabilité Génétique et Oncogenèse», Université Paris Sud (Paris XI), Gustave Roussy Cancer Campus, Villejuif, France.
Zhanat KoshenovNational Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Zhiger AkishevDepartment of Molecular Biology and Genetics, al-Farabi Kazakh National University, Faculty of Biology, Almaty, Kazakhstan.
Amangeldy K BissenbaevDepartment of Molecular Biology and Genetics, al-Farabi Kazakh National University, Faculty of Biology, Almaty, Kazakhstan.
Gerard MazonCNRS UMR 8200-Laboratoire «Stabilité Génétique et Oncogenèse», Université Paris Sud (Paris XI), Gustave Roussy Cancer Campus, Villejuif, France.
Nicolas E GeacintovChemistry Department, New York University, New York City, NY, USA.
Didier GasparuttoCEA, CNRS, INAC, SyMMES, Université Grenoble Alpes, Grenoble, France.
Regina GroismanGroupe «Réparation de l'ADN», Equipe Labellisée par la Ligue Nationale Contre le Cancer, CNRS UMR8200, Université Paris-Sud, Gustave Roussy Cancer Campus, Villejuif, France.
Dmitry O ZharkovSB RAS Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
Bakhyt T MatkarimovNational Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Murat SaparbaevGroupe «Réparation de l'ADN», Equipe Labellisée par la Ligue Nationale Contre le Cancer, CNRS UMR8200, Université Paris-Sud, Gustave Roussy Cancer Campus, Villejuif, France.
Nazarbayev University · KZAl-Farabi Kazakh National University · KZUniversité Paris-Sud · FRCentre National de la Recherche Scientifique · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRLa Ligue Contre le Cancer · FRNew York University · USNovosibirsk State University · RUStabilité génétique et oncogenèse · FR

Funding

Recognition of Environmental Carcinogen-DNA lesions by NER ProteinsR01ES024050 · NIEHS · NEW YORK UNIVERSITY · PI GEACINTOV, NICHOLAS E · 2014 to 2018
$1.8M
NIEHS NIH HHS R01 ES024050
6 · The paper itself

Abstract

backgroundDNA repair is essential to counteract damage to DNA induced by endo- and exogenous factors, to maintain genome stability. However, challenges to the faithful discrimination between damaged and non-damaged DNA strands do exist, such as mismatched pairs between two regular bases resulting from spontaneous deamination of 5-methylcytosine or DNA polymerase errors during replication. To counteract these mutagenic threats to genome stability, cells evolved the mismatch-specific DNA glycosylases that can recognize and remove regular DNA bases in the mismatched DNA duplexes. The

methodsHere, we investigated the role of MutY in UV-induced mutagenesis in

resultsWe demonstrated that MutY does not excise Adenine when it is paired with CPD and 6-4PP adducts in duplex DNA. At the same time, MutY excises Adenine in A•G and A•8oxoG mispairs. Interestingly, DISCUSSION: These findings indicate that the bacterial MutY is not involved in the aberrant DNA repair of UV-induced DNA damage.

Indexed as

Aberrant DNA repairAdenine-DNA glycosylaseBase excision repairCyclobutane pyrimidine dimerEscherichia coliNucleotide excision repairPyrimidine (6–4) pyrimidone photoproductUV-induced mutagenesis

Identifiers

PMID30568855
PMCPMC6286661
OpenAlexW2902956555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.