Evidence map›Paper›PMID 30568829›Full record

ArticleCurrent health sciences journal

A Comparative Study on Antibiotic Resistance of Klebsiella Strains from Surgical and Intensive Care Wards.

O M Cristea, O M Zlatian, S N Dinescu, A T Bălăşoiu, C Avramescu, M Bălăşoiu, M Niculescu, D Calina

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Article in Current health sciences journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Incidence of carbapenemase-resistant isolates ofNew microbes and new infections · 2026
    Article
  2. Article
  3. GenusMicroorganisms · 2026
    Article
  4. TEM,CTX-M,SHV Genes in ESBL-ProducingAntibiotics (Basel, Switzerland) · 2022
    Article
  5. Article
  6. Health care-associated infections - an overview.Infection and drug resistance · 2018
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

O M CristeaDepartment of Microbiology, University of Medicine and Pharmacy of Craiova, Romania.
O M ZlatianDepartment of Microbiology, University of Medicine and Pharmacy of Craiova, Romania.
S N DinescuDepartment of Epidemiology, University of Medicine and Pharmacy of Craiova, Romania.
A T BălăşoiuOphtalmology clinic, County Clinical Emergency Hospital of Craiova, Romania.
C AvramescuDepartment of Microbiology, University of Medicine and Pharmacy of Craiova, Romania.
M BălăşoiuDepartment of Microbiology, University of Medicine and Pharmacy of Craiova, Romania.
M NiculescuDepartment of Anatomy, University of Medicine and Pharmacy of Craiova, Romania.
D CalinaDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Romania.
University of Medicine and Pharmacy of Craiova · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKlebsiella infections are common in Intensive Care Unit (ICU) and surgical wards. In order to establish the prophylaxis protocols, we must know the prevalence of infections and the antibiotic resistance profiles. MATERIAL AND

methodsThis cross-sectional study included isolates from patients in County Clinical Emergency County Hospital, Craiova, Romania: 1254 isolates from the ICU and 1040 isolates from surgical wards. We used an automated method (Phoenix analyzer, Becton-Dickinson, USA) with antimicrobial testing according to CLSI 2014. We tested by disc diffusion the ESBL and carbapenemases production, using kits ESBL Confirm ID and KPC/Metallo-beta-lactamase/OXA-48 Confirm (ROSCO Diagnostica, Denmark). The patients in ICU were also screened at admission for carbapenemase producting strains by PCR (GeneXpert® II, Cepheid, Sunnyvale, CA, USA) for the carbapenemases: KPC, IMP-1, VIM-1, NDM, OXA-48.

resultsKlebsiella strains were more prevalent in ICU (20.81%) vs. surgical wards (16.34%) and they were resistant in high percentages at: cefuroxime (95.81% vs. 87.21%),ceftazidime (91.70% vs. 84.71%), cefepime (84.2% vs. 69.82%). The highest differences in resistance were observed for Tygecycline (Risk Ratio (RR) = 7.69), Imipenem/Cilastatine (RR=3.36), Cefoperazone with sulbactam (RR=2.58), Ciprofloxacine (RR=2.11), Gentamycin (RR=2.05) and Ertapenem (RR=1.93). The ICU strains showed MDR in 48.57% of cases vs. 23.57% in surgery strains. The prevalence of ESBL production was 82.4% in ICU vs. 32.3% in surgical wards. The prevalence of carbapenemase producing strains was 43.68% in ICU vs. 23.53% in surgical wards.

conclusionsThe infections with Klebsiella spp. are more frequent in ICU compared with surgical wards and their antibiotic resistance is greater.

Indexed as

antibiotic resistanceIntensive Care UnittKlebsiellaVentilatory Associated Pneumonia

Identifiers

PMID30568829
PMCPMC6256155
OpenAlexW3005546338

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.