Evidence map›Paper›PMID 30568760›Full record

ArticleMedChemComm2018

Structure activity relationship of 2-arylalkynyl-adenine derivatives as human A

Jinha Yu, Philip Mannes, Young-Hwan Jung, Antonella Ciancetta, Amelia Bitant, David I Lieberman, Sami Khaznadar, John A Auchampach, Zhan-Guo Gao, Kenneth A Jacobson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Fluorescent APurinergic signalling · 2023
    Article
  2. Interaction of AEuropean journal of medicinal chemistry · 2022
    Article
  3. Design and Synthesis of 2,6-Disubstituted-4'-Selenoadenosine-5'-Pharmaceuticals (Basel, Switzerland) · 2021
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Jinha YuMolecular Recognition Section , Laboratory of Bioorganic Chemistry , National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bldg. 8A, Rm. B1A-19, NIH, NIDDK, LBC , Bethesda , Maryland 20892-0810 , USA . Email: kennethj@niddk.nih.gov ; ; Tel: +301 496 9024.
Philip MannesMolecular Recognition Section , Laboratory of Bioorganic Chemistry , National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bldg. 8A, Rm. B1A-19, NIH, NIDDK, LBC , Bethesda , Maryland 20892-0810 , USA . Email: kennethj@niddk.nih.gov ; ; Tel: +301 496 9024.
Young-Hwan JungMolecular Recognition Section , Laboratory of Bioorganic Chemistry , National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bldg. 8A, Rm. B1A-19, NIH, NIDDK, LBC , Bethesda , Maryland 20892-0810 , USA . Email: kennethj@niddk.nih.gov ; ; Tel: +301 496 9024.
Antonella CiancettaSchool of Pharmacy , Queen's University Belfast , 96 Lisburn Rd , Belfast , BT9 7BL , UK.ORCID 0000-0002-7612-2050
Amelia BitantDepartment of Pharmacology , Medical College of Wisconsin , 8701 Watertown Plank Road , Milwaukee , Wisconsin 53226 , USA.
David I LiebermanMolecular Recognition Section , Laboratory of Bioorganic Chemistry , National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bldg. 8A, Rm. B1A-19, NIH, NIDDK, LBC , Bethesda , Maryland 20892-0810 , USA . Email: kennethj@niddk.nih.gov ; ; Tel: +301 496 9024.
Sami KhaznadarMolecular Recognition Section , Laboratory of Bioorganic Chemistry , National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bldg. 8A, Rm. B1A-19, NIH, NIDDK, LBC , Bethesda , Maryland 20892-0810 , USA . Email: kennethj@niddk.nih.gov ; ; Tel: +301 496 9024.
John A AuchampachDepartment of Pharmacology , Medical College of Wisconsin , 8701 Watertown Plank Road , Milwaukee , Wisconsin 53226 , USA.ORCID 0000-0002-8005-4599
Zhan-Guo GaoMolecular Recognition Section , Laboratory of Bioorganic Chemistry , National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bldg. 8A, Rm. B1A-19, NIH, NIDDK, LBC , Bethesda , Maryland 20892-0810 , USA . Email: kennethj@niddk.nih.gov ; ; Tel: +301 496 9024.
Kenneth A JacobsonMolecular Recognition Section , Laboratory of Bioorganic Chemistry , National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bldg. 8A, Rm. B1A-19, NIH, NIDDK, LBC , Bethesda , Maryland 20892-0810 , USA . Email: kennethj@niddk.nih.gov ; ; Tel: +301 496 9024.ORCID 0000-0001-8104-1493
National Institutes of Health · USMedical College of Wisconsin · USQueen's University Belfast · GB

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Role of Adenosine Receptors in Tissue ProtectionR01HL077707 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2005 to 2014
$3.4M
A3AR agonists to prevent chemotherapy-induced painful peripheral neuropathyR01CA169519 · NCI · SAINT LOUIS UNIVERSITY · PI SALVEMINI, DANIELA · 2013 to 2017
$1.5M
Intramural NIH HHS ZIA DK031117NCI NIH HHS R01 CA169519NHLBI NIH HHS R01 HL077707
6 · The paper itself

Abstract

Recognition of nucleosides at adenosine receptors (ARs) is supported by multiple X-ray structures, but the structure of an adenine complex is unknown. We examined the selectivity of predicted A

Identifiers

PMID30568760
PMCPMC6256369
OpenAlexW2896180529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.