ArticleFrontiers in immunology2018
Inflammatory Cytokine Profiles of Semen Influence Cytokine Responses of Cervicovaginal Epithelial Cells.
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Transient association between semen exposure and biomarkers of genital inflammation in South African women at risk of HIV infection.Journal of the International AIDS Society · 2021Trial
- Review
- Cytokine Concentrations in Seminal Plasma and Blood in HIV Infection: Differential Modulation by Antiretroviral Therapy and Association with HIV RNA Levels and CD4International journal of general medicine · 2026Article
- Review
- Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes.Frontiers in immunology · 2025Article
- The immunomodulatory role of seminal plasma in endometrial receptivity and embryo implantation.American journal of clinical and experimental immunology · 2025Review
- Contribution of the seminal microbiome to paternal programming.Biology of reproduction · 2024Review
- Utilization of Aminoguanidine Prevents Cytotoxic Effects of Semen.International journal of molecular sciences · 2022Article
- Women for science and science for women: Gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention.Frontiers in immunology · 2022Review
- Semen: A modulator of female genital tract inflammation and a vector for HIV-1 transmission.American journal of reproductive immunology (New York, N.Y. : 1989) · 2021Review
- Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants.Communications biology · 2021Article
- Recent Semen Exposure Impacts the Cytokine Response and Bacterial Vaginosis in Women.Frontiers in immunology · 2021Article
- The Role of Exosomal Epigenetic Modifiers in Cell Communication and Fertility of Dairy Cows.International journal of molecular sciences · 2020Review
- The Impact of Semen Exposure on the Immune and Microbial Environments of the Female Genital Tract.Frontiers in reproductive health · 2020Article
- Non-inflammatory Physiology of "Inflammatory" Mediators -Frontiers in immunology · 2020Article
- Immune Tolerance as the Physiologic Counterpart of Chronic Inflammation.Frontiers in immunology · 2020Article
- The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer.International journal of molecular sciences · 2019Review
- Extracellular vesicles in human semen modulate antigen-presenting cell function and decrease downstream antiviral T cell responses.PloS one · 2019Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genital inflammatory cytokine responses increase HIV risk. Since male partner semen is a complex mixture of immune-modulatory prostaglandins and cytokines, we hypothesized that exposure to semen may influence genital inflammation in women. Here, we investigated cytokine response kinetics of cervical cells following stimulation with seminal plasma from HIV-negative and HIV-positive men characterized as having low or high concentrations of inflammatory cytokines. Irrespective of the HIV status or semen cytokine profile,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.