Evidence map›Paper›PMID 30568608›Full record

ReviewFrontiers in psychiatry2018

The Role of Microbiome in Insomnia, Circadian Disturbance and Depression.

Yuanyuan Li, Yanli Hao, Fang Fan, Bin Zhang

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 124 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 2 pooled it
21.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05556733 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Faecal Microbiota Transplantation for Post-acute COVID-19 Syndrome: a Pilot Open-label Study

TypeinterventionalSponsorChinese University of Hong KongRan2022 to 2024Enrolled60ConditionsPost-Acute COVID19 Syndrome, COVID-19ArmsFaecal Microbiota Transplantation
NCT06905223 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Pilot Study on the Efficacy of a Synbiotic Formula (MQU10) in Improving Mood and Well-being in Adults With Mild to Moderate Depressive Symptoms

TypeinterventionalSponsorGenieBiome LimitedRan2025 to 2027Enrolled30ConditionsDepressive Symptoms Mild to Moderate in SeverityArmsMQU10
3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 2 syntheses or guidelines pooled it, 287 citations in OpenAlex.

  1. Pooled it
  2. WORKbiota: A Systematic Review about the Effects of Occupational Exposure on Microbiota and Workers' Health.International journal of environmental research and public health · 2022
    Pooled it
  3. Trial
  4. Trial
  5. Effects ofNutrients · 2021
    Trial
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Sleep Disorders in Climacteric Women: Glutathione, Glutathione S-Transferase P1 and Gut Microbiome Interrelation.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Article
  20. Review

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Yuanyuan LiKey Laboratory of Mental Health and Cognitive Science of Guangdong Province, and School of Psychology, Center for Studies of Psychological Application, South China Normal University, Guangdong, China.
Yanli HaoDepartment of Anatomy, Guangzhou Medical University, Guangdong, China.
Fang FanKey Laboratory of Mental Health and Cognitive Science of Guangdong Province, and School of Psychology, Center for Studies of Psychological Application, South China Normal University, Guangdong, China.
Bin ZhangDepartment of Psychiatry, Nanfang Hospital, Southern Medical University, Guangdong, China.
South China Normal University · CNGuangzhou Medical University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Good sleep and mood are important for health and for keeping active. Numerous studies have suggested that the incidence of insomnia and depressive disorder are linked to biological rhythms, immune function, and nutrient metabolism, but the exact mechanism is not yet clear. There is considerable evidence showing that the gut microbiome not only affects the digestive, metabolic, and immune functions of the host but also regulates host sleep and mental states through the microbiome-gut-brain axis. Preliminary evidence indicates that microorganisms and circadian genes can interact with each other. The characteristics of the gastrointestinal microbiome and metabolism are related to the host's sleep and circadian rhythm. Moreover, emotion and physiological stress can also affect the composition of the gut microorganisms. The gut microbiome and inflammation may be linked to sleep loss, circadian misalignment, affective disorders, and metabolic disease. In this review article, we discuss various functions of the gut microbiome and how its activities interact with the circadian rhythms and emotions of the host. Exploring the effects of the gut microbiome on insomnia and depression will help further our understanding of the pathogenesis of mental disorders. It is therefore important to regulate and maintain a normal gastrointestinal micro-ecological environment in patients when treating mental disorders.

Indexed as

circadian rhythmdepressiongut microbiomeinflammationinsomniamental healthmetabolic diseasemicrobiome-gut-brain axis

Identifiers

PMID30568608
PMCPMC6290721
OpenAlexW2901982449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.