Evidence map›Paper›PMID 30568463›Full record

ArticleOncoTargets and therapy2018

LncRNA ANCR promotes proliferation and radiation resistance of nasopharyngeal carcinoma by inhibiting PTEN expression.

Xingkai Ma, Jieyu Zhou, Jianyong Liu, Geping Wu, Yan Yu, Hongyan Zhu, Jisheng Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. [Curcumin-loaded nanoparticles reversed radiotherapy-triggered enhancement of MDR1 expression of CNE-2 cells in nasopharyngeal carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
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  11. The transcriptomic revolution and radiation biology.International journal of radiation biology · 2022
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  18. Long and short non-coding RNA and radiation response: a review.Translational research : the journal of laboratory and clinical medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Xingkai MaDepartment of Otorhinolaryngology, Zhangjiagang First People's Hospital, Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China, hongyanzhu1234@163.com.
Jieyu ZhouDepartment of Otorhinolaryngology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, P.R. China.
Jianyong LiuDepartment of Otorhinolaryngology, Zhangjiagang First People's Hospital, Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China, hongyanzhu1234@163.com.
Geping WuDepartment of Otorhinolaryngology, Zhangjiagang First People's Hospital, Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China, hongyanzhu1234@163.com.
Yan YuDepartment of Otorhinolaryngology, Zhangjiagang First People's Hospital, Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China, hongyanzhu1234@163.com.
Hongyan ZhuDepartment of Otorhinolaryngology, Zhangjiagang First People's Hospital, Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China, hongyanzhu1234@163.com.
Jisheng LiuDepartment of Otorhinolaryngology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China, ljswwq@sina.com.
Soochow University · CNZhangjiagang First People's Hospital · CNFirst Affiliated Hospital of Soochow University · CNShanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAntidifferentiation noncoding RNA (ANCR) is a newly identified long noncoding RNA, which is reported to function as an oncogene in multiple human cancers. However, its function in nasopharyngeal carcinoma (NPC) and underlying mechanism are still unclear. MATERIALS AND

methodsWe explored the expression of ANCR in NPC tissues and cells by real-time PCR and analyzed the relationship between ANCR expression and clinicopathological characteristics of NPC patients by Pearson's chi-squared test. Then we inhibited ANCR expression in NPC cells using siRNAs and evaluated the effect of ANCR expression on cell proliferation, colony formation, and radiosensitivity by cell counting kit-8 assay and colony formation assay. We used RT-PCR and Western blot analyses to search target genes of ANCR. Also, we used RNA immunoprecipitation (RIP) assay and chromatin immunoprecipitation assay to study the molecular mechanism in this regulation.

resultsWe found that ANCR was upregulated in NPC tissues and cells. ANCR expression was significantly correlated with tumor size and TNM stage. Further, ANCR knockdown inhibited NPC cell growth and radiation resistance. Mechanistically, we found that PTEN was upregulated in ANCR knockdown NPC cells. In addition, RIP assay indicated that EZH2, the oncogenic histone methyltransferase of polycomb repressive complex 2, interacted with ANCR in NPC cells. More importantly, the binding of EZH2 and deposition of relevant negative histone marker H3K27me3 on PTEN promoter depended on ANCR expression.

conclusionANCR expression is upregulated in NPC and promotes NPC growth and radiation resistance through an epigenetic regulation of PTEN expression.

Indexed as

antidifferentiation noncoding RNAgrowthnasopharyngeal carcinomaphosphatase and tensin homologradiation resistance

Identifiers

PMID30568463
PMCPMC6267624
OpenAlexW2902977134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.