Evidence map›Paper›PMID 30568448›Full record

ArticleNeuropsychiatric disease and treatment2018

Association of HLA alleles with autism.

Arezou Sayad, Mohammad Taghi Akbari, Rezvan Noroozi, Mir Davood Omrani, Hidetoshi Inoko, Mohammad Taheri, Soudeh Ghafouri-Fard

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Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Arezou SayadDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran, s.ghafourifard@sbmu.ac.ir.
Mohammad Taghi AkbariDepartment of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Rezvan NorooziPhotochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mir Davood OmraniDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran, s.ghafourifard@sbmu.ac.ir.
Hidetoshi InokoDepartment of Molecular Life Science, Tokai University, Hiratsuka, Japan.
Mohammad TaheriStudent Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran, mohammad_823@yahoo.com.
Soudeh Ghafouri-FardDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran, s.ghafourifard@sbmu.ac.ir.
Shahid Beheshti University of Medical Sciences · IRTokai University · JPTarbiat Modares University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its pathogenesis.

methodsAmong them are certain human leukocyte antigen (HLA) alleles. In the current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients and 180 age, gender, and ethnic-matched healthy controls.

resultsAfter Boferroni correction no allele or haplotype was associated with genetic susceptibility to ASD in Iranian population.

conclusionFuture studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis.

Indexed as

autismHLA typingimmune response

Identifiers

PMID30568448
PMCPMC6267725
OpenAlexW2902748112

What OpenQuestion holds

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