ReviewClinical interventions in aging2018
The good, the bad, and the ugly of calcium supplementation: a review of calcium intake on human health.
Review in Clinical interventions in aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 181 citations in OpenAlex.
- Calcium Supplementation in Pregnancy: A Systematic Review of Clinical Studies.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Trial
- Effects of calcium supplementation on changes in the IL2, IL4, IL6, IL10 axes and oxidative stress in pregnant women at risk for pre-eclampsia.BMC pregnancy and childbirth · 2024Trial
- Relative bioavailability and pharmacokinetic comparison of calcium glucoheptonate with calcium carbonate.Pharmacology research & perspectives · 2020Trial
- Preparation optimization, structural characterization, stability and promoting calcium absorption mechanism of sturgeon cartilage peptide-calcium chelates.Food chemistry: X · 2026Article
- Commercial Edible Seaweeds: Characterization by Mineral Content and Fatty Acid Composition.Foods (Basel, Switzerland) · 2026Article
- Management of glucocorticoid-induced osteoporosis in rheumatic diseases.Best practice & research. Clinical rheumatology · 2026Review
- Eliminating Animal Products from the Diet Puts Dutch Older Adults at Risk of Micronutrient Deficiencies: A Simulation Study.Current developments in nutrition · 2026Article
- Vascularity Assessment of Parathyroid Glands Using Low-Dose ICG and Probe-Based Fluorescence Detection.Annals of surgical oncology · 2026Article
- Key determinants for lowering the risk of joint replacement in weight-bearing joints: a population-based cohort study.Arthroplasty (London, England) · 2026Article
- Nutritional profiling, bioactive phytochemicals, and functional food components of wild edible fruits from the Indo-Burma biodiversity hotspot.Scientific reports · 2026Article
- Associations of coffee, alcohol, medication and supplement use with the metabolome and lipidome: an observational study of premenopausal women.Metabolomics : Official journal of the Metabolomic Society · 2026Observational
- Image-guided in vivo evaluation and comparison of bone-targeting peptides for therapeutic intervention.Drug delivery and translational research · 2026Article
- Concurrent Calcium and Magnesium Determination by Ion Chromatography: An Approach to Avoid Interferences That Compromise Analysis.Biomedical chromatography : BMC · 2026Article
- Sustained and reversible effects of a dietary phosphate intake on bone and mineral metabolism during aging.GeroScience · 2026Article
- Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Article
- Association between daily calcium intake and the prevalence of chronic diarrhea: an analysis of NHANES 2005-2010 data.BMC gastroenterology · 2025Article
- Clinical significance and risk factors of incidental parathyroidectomy after total thyroidectomy.Endocrine · 2025Article
- No independent association between dietary calcium/vitamin D and appendicular lean mass index in middle-aged women: NHANES cross-sectional analysis (2011-2018).Scientific reports · 2025Article
- Surface water quality evaluation of the historic Esinmirin River of antiquity, Ile-Ife, Nigeria.Heliyon · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
Calcium is an important integrative component of the human body and critical for human health. It has been well established that calcium intake is helpful in the prevention and treatment of osteoporosis, which has become one of the most serious public health problems across the world. However, community-dwelling adults with and without osteoporosis are rarely concerned or even not aware of the potential side effects of high or inappropriate doses of calcium intake. Some recent studies have revealed that excessive calcium intake might increase the risks of cardiovascular diseases. The purpose of this article was to review the health benefits, costs, and consequences of calcium supplementation on osteoporosis/osteoporotic fractures, cardiovascular events, kidney stones, gastrointestinal diseases, and other important diseases. In the end, we suggest that calcium supplementation should be prescribed and taken cautiously, accounting for individual patients' risks and benefits. Clearly, further studies are needed to examine the health effects of calcium supplementation to make any solid recommendations for people of different genders, ages, and ethnicities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.