Evidence map›Paper›PMID 30568391›Full record

ArticleWorld journal of gastroenterology2018

Pelvic exenterations for primary rectal cancer: Analysis from a 10-year national prospective database.

Gianluca Pellino, Sebastiano Biondo, Antonio Codina Cazador, José María Enríquez-Navascues, Eloy Espín-Basany, Jose Vicente Roig-Vila, Eduardo García-Granero, Rectal Cancer Project

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Observational
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Gianluca PellinoColorectal Unit, Hospital Universitario y Politecnico La Fe, University of Valencia, Valencia 46026, Spain.
Sebastiano BiondoDepartment of General and Digestive Surgery, Colorectal Unit, Bellvitge University Hospital, University of Barcelona and IDIBELL, L'Hospitalet de Llobregat, Barcelona 08907, Spain.
Antonio Codina CazadorDepartment of General and Digestive Surgery--Colorectal Unit, Josep Trueta University Hospital, Girona 17001, Spain.
José María Enríquez-NavascuesGeneral and Digestive Surgery Department, Donostia University Hospital, Donostia 20014, Spain.
Eloy Espín-BasanyDepartment of General Surgery, Colorectal Surgery Unit, Hospital Valle de Hebron, Autonomous University of Barcelona, Barcelona 08035, Spain.
Jose Vicente Roig-VilaUnit of Coloproctology, Hospital Vithas-Nisa 9 de Octubre, Valencia 46015, Spain.
Eduardo García-GraneroColorectal Unit, Hospital Universitario y Politecnico La Fe, University of Valencia, Valencia 46026, Spain. eggranero@telefonica.net.
Rectal Cancer Project
Hospitales Nisa · ESBiogipuzkoa Health Research Institute · ESHospital Universitari i Politècnic La Fe · ESInstitut d'Investigació Biomédica de Bellvitge · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo identify short-term and oncologic outcomes of pelvic exenterations (PE) for locally advanced primary rectal cancer (LAPRC) in patients included in a national prospective database.

methodsFew studies report on PE in patients with LAPRC. For this study, we included PE for LAPRC performed between 2006 and 2017, as available, from the Rectal Cancer Registry of the Spanish Association of Surgeons [Asociación Española de Cirujanos (AEC)]. Primary endpoints included procedure-associated complications, 5-year local recurrence (LR), disease-free survival (DFS) and overall survival (OS). A propensity-matched comparison with patients who underwent non-exenterative surgery for low rectal cancers was performed as a secondary endpoint.

resultsEight-two patients were included. The mean age was 61.8 ± 11.5 years. More than half of the patients experienced at least one complication. Surgical site infections were the most common complication (abdominal wound 18.3%, perineal closure 19.4%). Thirty-three multivisceral resections were performed, including two hepatectomies and four metastasectomies. The long-term outcomes of the 64 patients operated on before 2013 were assessed. The five-year LR was 15.6%, the distant recurrence rate was 21.9%, and OS was 67.2%, with a mean survival of 43.8 mo. R+ve resection increased LR [hazard ratio (HR) = 5.58, 95%CI: 1.04-30.07,

conclusionPE is an extensive procedure, justified if disease-free margins can be obtained. Further studies should define indications, accreditation policy, and quality of life in LAPRC.

Indexed as

AgedDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPelvic ExenterationPerioperative PeriodPostoperative ComplicationsProspective StudiesQuality of LifeRectal NeoplasmsRectumRetrospective StudiesAdvanced rectal cancerColorectal surgeryComplicationOutcomePelvic exenteration

Identifiers

PMID30568391
PMCPMC6288654
OpenAlexW2904539466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.