Evidence map›Paper›PMID 30568345›Full record

ArticleJournal of clinical and experimental hepatology2018

INASL Guidelines on Management of Hepatitis B Virus Infection in Patients receiving Chemotherapy, Biologicals, Immunosupressants, or Corticosteroids.

Anil Arora, Anil C Anand, Ashish Kumar, Shivaram P Singh, Rakesh Aggarwal, Radha K Dhiman, Shyam Aggarwal, Seema Alam, Pradeep Bhaumik, Vinod K Dixit and 16 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical and experimental hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Hepatitis B Virus Screening and Management for Patients With Cancer Prior to Therapy: ASCO Provisional Clinical Opinion Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020
    Guideline
  2. HBV/HCV coinfection and anti-tuberculosis drug-induced liver injury: from risk assessment and exploration of mechanisms to preventive considerations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Acute-on-chronic liver failure due to hepatitis B.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. A comprehensive review of vaccination in patients with inflammatory bowel diseases:  An Indian perspective.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Managing HBV and HCV Infection Pre- and Post-liver Transplant.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 19 institutions in 1 country.

Anil AroraInstitute of Liver Gastroenterology & Pancreatico Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, India.
Anil C AnandIndraprastha Apollo Hospital, New Delhi, India.
Ashish KumarInstitute of Liver Gastroenterology & Pancreatico Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, India.
Shivaram P SinghDepartment of Gastroenterology, S.C.B. Medical College, Cuttack, India.
Rakesh AggarwalDepartment of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Radha K DhimanDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Shyam AggarwalDepartment of Medical Oncology, Sir Ganga Ram Hospital, New Delhi, India.
Seema AlamDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Pradeep BhaumikDepartment of Medicine, Agartala Govt. Medical College (AGMC), Agartala, India.
Vinod K DixitDepartment of Gastroenterology, Institute of Medical Sciences Banaras Hindu University, Varanasi, India.
Ashish GoelDepartment of Hepatology, Christian Medical College, Vellore, India.
Bhabadev GoswamiDepartment of Gastoenterology, Gauhati Medical College, Guwahati, India.
Ashok KumarDepartment of Rheumatology, Fortis Flt Lt Rajan Dhall Hospital, New Delhi, India.
Manoj KumarDepartment of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, India.
Kaushal MadanGastroenterology & Hepatology, Max Smart Super Speciality Hospital, New Delhi, India.
Natarajan MuruganHepatology and Liver transplant, Apollo Hospitals, Chennai, India.
Aabha NagralDepartment of Gastroenterology, Jaslok and Apollo Hospitals, Mumbai, India.
Amarender S PuriDepartment of Gastroenterology, G.B. Pant Hospital, New Delhi, India.
Padaki N RaoHepatology, Asian Institute Of Gastroenterology, Hyderabad, India.
Neeraj SarafHepatology, Medanta - The Medicity, Gurugram, India.
Vivek A SaraswatDepartment of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Sanjeev SehgalInstitute of Liver Transplantation and Regenerative Medicine, Medanta - The Medicity, Gurugram, India.
Praveen SharmaInstitute of Liver Gastroenterology & Pancreatico Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, India.
Koticherry T ShenoySree Gokulam Medical College and Research Foundation, Trivandrum, India.
Manav WadhawanHepatology & Liver Transplant (Medicine), Fortis Escorts Liver & Digestive Diseases Institute (FELDI), Fortis Escorts Hospital, Delhi, India.
Members of the INASL taskforce on Hepatitis B
Sir Ganga Ram Hospital · INInstitute of Liver and Biliary Sciences · INSanjay Gandhi Post Graduate Institute of Medical Sciences · INAgartala Government Medical College · INApollo Hospitals · INApollo Hospitals · INAsian Institute of Gastroenterology · INChristian Medical College & Hospital · INFortis Escorts Hospital · INGauhati Medical College and Hospital · INGovind Ballabh Pant Hospital · INIndraprastha Apollo Hospitals · INInstitute of Medical Sciences · INMax Super Speciality Hospital · INMedanta The Medicity · INMedanta The Medicity · INPost Graduate Institute of Medical Education and Research · INSree Gokulam Medical College and Research Foundation · INSriram Chandra Bhanja Medical College Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B Virus (HBV) reactivation in patients receiving chemotherapy, biologicals, immunosupressants, or corticosteroids is emerging to be an important cause of morbidity and mortality in patients with current or prior exposure to HBV infection. These patients suffer a dual onslaught of illness: one from the primary disease for which they are receiving the culprit drug that led to HBV reactivation, and the other from HBV reactivation itself. The HBV reactivation not only leads to a compromised liver function, which may culminate into hepatic failure; it also adversely impacts the treatment outcome of the primary illness. Hence, identification of patients at risk of reactivation before starting these drugs, and starting treatment aimed at prevention of HBV reactivation is the best strategy of managing these patients. There are no Indian guidelines on management of HBV infection in patients receiving chemotherapy, biologicals, immunosupressants, or corticosteroids for the treatment of rheumatologic conditions, malignancies, inflammatory bowel disease, dermatologic conditions, or solid-organ or bone marrow transplantation. The Indian National Association for Study of the Liver (INASL) had set up a taskforce on HBV in 2016, with a mandate to develop consensus guidelines for management of various aspects of HBV infection, relevant to India. In 2017 the taskforce had published the first INASL guidelines on management of HBV infection in India. In the present guidelines, which are in continuation with the previous guidelines, the issues on management of HBV infection in patients receiving chemotherapy, biologicals, immunosupressants, or corticosteroids are addressed.

Indexed as

ACLF, Acute-on-Chronic Liver FailureAFP, AlphafetoproteinALT, Alanine AminotransferaseAnti-HBc, Antibodies to Hepatitis B Core AntigenAnti-HBs, Antibodies to Hepatitis B Surface AntigencancercccDNA, Covalently Closed Circular Deoxyribonucleic AcidCHB, Chronic Hepatitis BchemotherapyCHOP, Cyclophosphamide, Doxorubicin, Vincristine, and PrednisoneCKD, Chronic Kidney DiseaseDILI, Drug-Induced Liver InjuryDNA, Deoxyribonucleic AcidETV, EntecavirGRADE, Grading of Recommendations, Assessment, Development and EvaluationHAV, Hepatitis A VirusHBcAg, Hepatitis B Core AntigenHBeAg, Hepatitis B Envelope AntigenHBIG, Hepatitis B Immune GlobulinHBsAg, Hepatitis B Surface AntigenHBV DNA, Hepatitis B Virus Deoxyribonucleic AcidHBV, Hepatitis B VirusHDV, Hepatitis D Virushepatitis BHEV, Hepatitis E VirusHLA, Human Leukocyte Antigen Class IimmunosupressantsINASL, Indian National Association for Study of the LiverLAM, Lamivudineliver failureNAs, Nucleos(t)ide AnalogsNHL, Non-Hodgkin’s LymphomaNK, Natural KillerPegIFN-α, Pegylated Interferon AlphaRA, Rheumatoid ArthritisrcDNA, Relaxed-Circular Deoxyribonucleic AcidSLE, Systemic Lupus ErythematosusTAF, Tenofovir AlafenamideTDF, Tenofovir Disoproxil FumarateTLC, Total Leucocyte CountULN, Upper Limit of Normal

Identifiers

PMID30568345
PMCPMC6286881
OpenAlexW2810023035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.