ArticleInternational journal of obesity (2005)2019
BMI-related cortical morphometry changes are associated with altered white matter structure.
Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The association between motor coordination, behavior, cognition and brain structure in children: an ABCD study.European child & adolescent psychiatry · 2026Article
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging.Neurobiology of aging · 2024Article
- Article
- Correlates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health.Cerebral circulation - cognition and behavior · 2024Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults.Cerebral circulation - cognition and behavior · 2023Article
- Vascular health and diffusion properties of normal appearing white matter in midlife.Brain communications · 2021Article
- Neurocognitive Inhibitory Control Ability Performance and Correlations with Biochemical Markers in Obese Women.International journal of environmental research and public health · 2020Article
- Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood.Developmental cognitive neuroscience · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundWhile gross measures of brain structure have shown alterations with increasing body mass index (BMI), the extent and nature of such changes has varied substantially across studies. Here, we sought to determine whether small-scale morphometric measures might prove more sensitive and reliable than larger scale measures and whether they might offer a valuable opportunity to link cortical changes to underlying white matter changes. To examine this, we explored the association of BMI with millimetre-scale Gaussian curvature, in addition to standard measures of morphometry such as cortical thickness, surface area and mean curvature. We also assessed the volume and integrity of the white matter, using white matter signal intensity and fractional anisotropy (FA). We hypothesised that BMI would be linked to small-scale changes in Gaussian curvature and that this phenomenon would be mediated by changes in the integrity of the underlying white matter.
methodsThe association of global measures of T1-weighted cortical morphometry with BMI was examined using linear regression and mediation analyses in two independent groups of healthy young to middle aged human subjects (n
resultsGaussian curvature of the white matter surface showed a significant, positive association with BMI across all three independent datasets. This effect was mediated by a negative association between the integrity of the white matter and BMI.
conclusionsIncreasing BMI is associated with changes in white matter microstructure in young to middle-aged healthy adults. Our results are consistent with a model whereby BMI-linked cortical changes are mediated by the effects of BMI on white matter microstructure.
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