ArticleNature communications2018
Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 4 of them syntheses that pooled it.
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115citing papers in PubMed, 4 pooled it
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Who cites it
115 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Genomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review.Biological psychiatry · 2026Pooled it
- Association of apolipoprotein E variants on Alzheimer's disease in Latin America: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Machado-Joseph disease in Brazil and other South American countries: A systematic Review and Meta-analysis of Prevalence, CAG Repeat Lengths, Age At Onset, and Ancestry.Cerebellum (London, England) · 2025Pooled it
- Population genetic considerations for using biobanks as international resources in the pandemic era and beyond.BMC genomics · 2021Pooled it
- Trans-Eurasian steppe herder and barley farmer migrations shaped paternal genomic dynamics in Northwest China and Hui evolution.Science advances · 2026Article
- Genetic Diversity Analysis of Risk Variants Associated with Bone and Cartilage Metabolism in Nine Mexican Subpopulations.Biomedicines · 2026Article
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- Cognitive changes associated with chemotherapy in breast cancer: an assessment of social cognition and executive functions in Peruvian patients.The oncologist · 2026Article
- STRIPE partners in precision medicine: international perspective.The pharmacogenomics journal · 2026Review
- KANN: estimation of genetic ancestry profiles by nearest neighbor regression.Nucleic acids research · 2026Article
- Host Immunogenetic Profile Modulates Susceptibility to Apical Periodontitis in a Colombian Population.Current issues in molecular biology · 2026Article
- Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Exploring the genomic population structure and history of Austroasiatic speakers in Mainland Southeast Asia.Communications biology · 2026Article
- Genetic diversity and differentiated adaptive strategies for underrepresented populations at the crossroad of Southeast and East Asia.BMC genomics · 2026Article
- Differentiating the demographic histories and local adaptations of middle-altitude Qiang and Tibetan people.Human genetics · 2025Article
- Admixture Mapping of Lipid Traits in Hispanic Americans.Journal of the American Heart Association · 2025Article
- Evolution of hepatology practice in Mexico and Latin America: From biochemical markers to genomic medicine.World journal of hepatology · 2025Review
- Genetic ancestry influences body shape and obesity risk in Latin American populations.Scientific reports · 2025Article
- Characterization of the mutational status of glioblastoma and high-grade astrocytomas in a Latin American cohort.Scientific reports · 2025Article
55 more citing papers are in PubMed but not listed here.
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Authors and funding
50 authors.
Juan-Camilo Chacón-DuqueDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UK.ORCID http://orcid.org/0000-0003-0715-1947
Kaustubh AdhikariDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UK.ORCID http://orcid.org/0000-0001-5825-4191
Macarena Fuentes-GuajardoDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UK.
Javier Mendoza-RevillaDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UK.
Victor Acuña-AlonzoDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UK.
Rodrigo BarqueraMolecular Genetics Laboratory, Escuela Nacional de Antropología e Historia, Mexico City, 14030, Mexico.ORCID http://orcid.org/0000-0003-0518-4518
Mirsha Quinto-SánchezCiencia Forense, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico.
Jorge Gómez-ValdésPosgrado en Antropología Física, Escuela Nacional de Antropología e Historia, Mexico City, 14030, Mexico.ORCID http://orcid.org/0000-0001-6996-2732
Paola Everardo MartínezPosgrado en Antropología, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico.
Hugo Villamil-RamírezUnidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de México e Instituto Nacional de Medicina Genómica, Mexico City, 04510, Mexico.
Tábita HünemeierDepartamento de Genética e Biología Evolutiva, Instituto de Biociências, Universidade de São Paulo, Sao Paulo, 05508-090, Brazil.
Virginia RamalloInstituto Patagónico de Ciencias Sociales y Humanas-Centro Nacional Patagónico, CONICET, Puerto Madryn, U912OACD, Argentina.
Caio C Silva de CerqueiraDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 91501-970, Brazil.
Malena HurtadoLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Peru.
Valeria VillegasLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Peru.
Vanessa GranjaLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Peru.
Mercedes VillenaInstituto Boliviano de Biología de Altura (IBBA), Universidad Mayor de San Andrés (UMSA), La Paz, 2070, Bolivia.
René VásquezInstituto Boliviano de Biología de Altura (IBBA), Universidad Autónoma Tomás Frías, Potosí, 53820, Bolivia.
Elena LlopPrograma de Genetica Humana, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, 1027, Chile.
José R SandovalFacultad de Medicina Humana, Universidad de San Martín de Porres, Lima, 12, Peru.ORCID http://orcid.org/0000-0003-2673-4937
Alberto A Salazar-GranaraFacultad de Medicina Humana, Universidad de San Martín de Porres, Lima, 12, Peru.
Maria-Laura ParolinInstituto de Diversidad y Evolución Austral (IDEAus), Centro Nacional Patagónico, CONICET, Puerto Madryn, U912OACD, Argentina.
Karla SandovalNational Laboratory of Genomics and Biodiversity (LANGEBIO), CINVESTAV, Irapuato, 36821, Mexico.
Rosenda I Peñaloza-EspinosaDepartment of Biological Systems, Division of Biological and Health Sciences, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, 04960, Mexico.
Hector Rangel-VillalobosInstituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, 1115, Mexico.
Cheryl A WinklerBasic Research Laboratory, National Cancer Institute, Frederick National Laboratory, Frederick, MD, 21702, USA.
William KlitzIntegrative Biology, University of California, Berkeley, CA, 94720, USA.
Claudio BraviInstituto Multidisciplinario de Biología Celular, CONICET, La Plata, B1906APO, Argentina.
Julio MolinaCentro de Investigaciones Biomédicas de Guatemala, Ciudad de Guatemala, 01011, Guatemala.
Daniel CorachServicio de Huellas Digitales Genéticas and CONICET, Universidad de Buenos Aires, Buenos Aires, C1113AAD, Argentina.
Ramiro BarrantesEscuela de Biología, Universidad de Costa Rica, San José, 2060, Costa Rica.
Verónica GomesInstituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, 4200-135, Portugal.ORCID http://orcid.org/0000-0003-2815-6376
Carlos ResendeInstituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, 4200-135, Portugal.
Leonor GusmãoInstituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, 4200-135, Portugal.
Antonio AmorimInstituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, 4200-135, Portugal.ORCID http://orcid.org/0000-0002-7518-6247
Yali XueThe Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Jean-Michel DugoujonCentre National de la Recherche Scientifique, Université Toulouse 3 Paul Sabatier, Toulouse, 31330, France.
Pedro MoralDepartamento de Biología Evolutiva, Ecología y Ciencias Ambientales, Universitat de Barcelona, Barcelona, 08007, Spain.
Rolando González-JoséInstituto Patagónico de Ciencias Sociales y Humanas-Centro Nacional Patagónico, CONICET, Puerto Madryn, U912OACD, Argentina.
Lavinia Schuler-FacciniDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 91501-970, Brazil.
Francisco M SalzanoDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 91501-970, Brazil.
Maria-Cátira BortoliniDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 91501-970, Brazil.
Samuel Canizales-QuinterosUnidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de México e Instituto Nacional de Medicina Genómica, Mexico City, 04510, Mexico.
Giovanni PolettiLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Peru.
Carla GalloLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Peru.
Gabriel BedoyaGenética Molecular (GENMOL), Universidad de Antioquia, Medellín, 5001000, Colombia.
Francisco RothhammerPrograma de Genetica Humana, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, 1027, Chile.
David BaldingDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UK.ORCID http://orcid.org/0000-0002-1480-6115
Garrett HellenthalDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UK. g.hellenthal@ucl.ac.uk.
Andrés Ruiz-LinaresMinistry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, 200433, China. andresruiz@fudan.edu.cn.
Funding
Genetics of Renal Disease in African AmericansZIABC010022 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINKLER, CHERYL · 2009 to 2022
$8.9MWellcome Trust
Abstract
Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.
Indexed as
Human MigrationHaplotypesHumansIndians, North AmericanIndians, South AmericanMexicoNoseSouth America
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