ArticleGenes & development2019
PRC1 preserves epidermal tissue integrity independently of PRC2.
Article in Genes & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 40 citations in OpenAlex.
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- The origins of skin diversity: lessons from dermal fibroblasts.Development (Cambridge, England) · 2022Article
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- The molecular principles of gene regulation by Polycomb repressive complexes.Nature reviews. Molecular cell biology · 2021Review
- TBX2 controls a proproliferative gene expression program in melanoma.Genes & development · 2021Article
- Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma.Cancers · 2021Review
- RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4Nature cancer · 2021Article
- UV-induced reduction in Polycomb repression promotes epidermal pigmentation.Developmental cell · 2021Article
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- Epigenetic and metabolic regulation of epidermal homeostasis.Experimental dermatology · 2021Review
- Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function.eLife · 2021Article
- PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus.Nature communications · 2021Article
- Polycomb complexes redundantly maintain epidermal stem cell identity during development.Genes & development · 2021Article
- The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies.Life science alliance · 2021Article
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7 authors at 5 institutions in 2 countries.
Funding
Abstract
Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene expression and tissue development. Here, we show that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is dispensable. Loss of PRC1 resulted in blistering skin, reminiscent of human skin fragility syndromes. Conversely, PRC1 does not restrict epidermal stratification during skin morphogenesis, whereas PRC2 does. Molecular dissection demonstrated that PRC1 functions with PRC2 to silence/dampen expression of adhesion genes. In contrast, PRC1 promotes expression of critical epidermal adhesion genes independently of PRC2-mediated H3K27me3. Together, we demonstrate a functional link between epigenetic regulation and skin diseases.
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