ArticleCancer discovery2019
Open access · bronzeAbstract read
In one paragraph
Article in Cancer discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 74 citations in OpenAlex.
- Phf6 truncating mutation drives leukemogenesis via disrupted epigenetic regulation in mice.Leukemia · 2026Article
- PHF6 interacts with the LMO2 complex in T-cell acute lymphoblastic leukemia.Haematologica · 2026Article
- Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness.Genes & development · 2025Article
- PHF6 and RUNX1 mutations cooperate to accelerate leukemogenesis.Translational oncology · 2025Article
- Article
- PHF6 suppresses self-renewal of leukemic stem cells in AML.Leukemia · 2024Article
- PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression.Nature communications · 2024Article
- Genomic and global gene expression profiling in pediatric and young adult acute leukemia with PICALM::MLLT10 Fusion.Leukemia · 2024Article
- Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting.Nature communications · 2024Article
- PHF6 loss reduces leukemia stem cell activity in an acute myeloid leukemia mouse model.Cancer cell international · 2024Article
- PHF6 suppresses self-renewal of leukemic stem cells in AML.bioRxiv : the preprint server for biology · 2024Article
- Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study.Signal transduction and targeted therapy · 2023Article
- Article
- R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.iScience · 2023Article
- Article
- PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer.Journal of translational medicine · 2023Article
- Statistical Methods Inspired by Challenges in Pediatric Cancer Multi-omics.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A comprehensive pan-cancer analysis unveiling the oncogenic effect of plant homeodomain finger protein 14 (PHF14) in human tumors.Frontiers in genetics · 2023Article
- Targeting Leukemia-Initiating Cells and Leukemic Niches: The Next Therapy Station for T-Cell Acute Lymphoblastic Leukemia?Cancers · 2022Review
- Epigenetic reversal of hematopoietic stem cell aging in Phf6-knockout mice.Nature aging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 10 institutions in 4 countries.
Agnieszka A WendorffInstitute for Cancer Genetics, Columbia University, New York, New York.
S Aidan QuinnInstitute for Cancer Genetics, Columbia University, New York, New York.
Marissa RashkovanInstitute for Cancer Genetics, Columbia University, New York, New York.
Chioma J MadubataDepartment of Systems Biology, Columbia University, New York, New York.
Alberto Ambesi-ImpiombatoInstitute for Cancer Genetics, Columbia University, New York, New York.
Mark R LitzowDivision of Hematology, Mayo Clinic, Rochester, Minnesota.
Martin S TallmanDepartment of Hematologic Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Elisabeth PaiettaDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York.
Maddalena PaganinOnco-Hematology Division, Department, Salute della Donna e del Bambino (SDB), University of Padua, Padua, Italy.
Giuseppe BassoOnco-Hematology Division, Department, Salute della Donna e del Bambino (SDB), University of Padua, Padua, Italy.
Julie M Gastier-FosterDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio.
Mignon L LohDepartment of Pediatrics, University of California, San Francisco, California.
Raul RabadanDepartment of Systems Biology, Columbia University, New York, New York.
Pieter Van VlierbergheCenter for Medical Genetics Ghent, Ghent University, Ghent, Belgium.
Adolfo A FerrandoInstitute for Cancer Genetics, Columbia University, New York, New York. af2196@columbia.edu.
Cancer Genetics (United States) · USColumbia University · USColumbia University Irving Medical Center · USUniversity of Padua · ITAlbert Einstein College of Medicine · USChildren's Oncology Group · CHGhent University Hospital · BEMayo Clinic · USMemorial Sloan Kettering Cancer Center · USUniversity of California, San Francisco · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MCOG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5MProject-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer · 2014 to 2026
$167.6MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3MTumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MECOG-ACRIN Biospecimen Bank to Support NCTNU24CA196172 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI STANLEY R. HAMILTON, Scott D Jewell · 2015 to 2026
$41.1MSupport for Human Specimen Banking in NCI-Supported Cancer Clinical TrialsU24CA114766 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RAMIREZ MILAN, NILSA DEL CARMEN · 2005 to 2014
$14.5MSystematic pharmacological targeting of the core mechanisms responsible for maintaining cancer cell stateU54CA209997 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA, HONIG, BARRY H · 2016 to 2021
$10.9MMontefiore Academic Community NCORP ProgramUG1CA189859 · NCI · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI Balazs Halmos, Della Makower · 2014 to 2026
$10.8MTopology of Cancer Evolution and HeterogeneityU54CA193313 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO, RABADAN, RAUL · 2015 to 2020
$10.4MNetwork Lead Academic Participating Site: Memorial Sloan Kettering Cancer CenterUG1CA233290 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CAROL AGHAJANIAN, Darren Feldman · 2019 to 2026
$10.2MECOG-ACRIN Integrated Leukemia Translational Science Center (LTSC)UG1CA233332 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CAI, SHENG, LEVINE, ROSS L · 2019 to 2025
$6.2MNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA013696NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA155743NCI NIH HHS R01 CA185486NCI NIH HHS R35 CA210065NCI NIH HHS U01 CA217858NCI NIH HHS U10 CA014958NCI NIH HHS U10 CA017145NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180791NCI NIH HHS U10 CA180820NCI NIH HHS U10 CA180827NCI NIH HHS U24 CA114766NCI NIH HHS U24 CA196172NCI NIH HHS U54 CA193313NCI NIH HHS U54 CA209997NCI NIH HHS UG1 CA189859NCI NIH HHS UG1 CA233290NCI NIH HHS UG1 CA233332
Abstract
The plant homeodomain 6 gene (
Indexed as
Cell Self RenewalAnimalsCell Transformation, NeoplasticFemaleHematopoietic Stem CellsHumansMaleMice, Inbred C57BLMice, KnockoutMutationNeoplastic Stem CellsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaRepressor ProteinsTumor Cells, CulturedPHF6 protein, humanPhf6 protein, mouseRepressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.