Evidence map›Paper›PMID 30567821›Full record

ArticleBMJ open2018

Clinical, neurocognitive and demographic factors associated with functional impairment in the Australian Brain and Mind Youth Cohort Study (2008-2016).

Rico S C Lee, Daniel F Hermens, Sharon L Naismith, Manreena Kaur, Adam J Guastella, Nick Glozier, Jan Scott, Elizabeth M Scott, Ian B Hickie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rico S C LeeBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Daniel F HermensBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Sharon L NaismithBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Manreena KaurBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Adam J GuastellaBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Nick GlozierBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Jan ScottAcademic Psychiatry, Institute of Neuroscience, Newcastle University, Newcastle, UK.
Elizabeth M ScottBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Ian B HickieBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe sought to determine the unique and shared contributions of clinical, neurocognitive and demographic factors to functional impairment in a large, transdiagnostic, clinical cohort of adolescents and young adults.

designCross-sectional baseline data from a prospective, cohort study.

settingHelp-seeking youth referred from outpatient services were recruited to the

participantsIn total, 1003 outpatients were recruited, aged between 12 and 36 years (mean= 20.4 years, 54% female), with baseline diagnoses of affective, psychotic, developmental or behavioural disorders.

interventionsTreatment as usual. PRIMARY OUTCOME MEASURES: Social and occupational functioning was used to index level of functional impairment. Structural equation modelling was used to examine associations between neurocognition, core clinical symptoms and alcohol and substance use, and clinician-rated and researcher-rated functional impairment. Moderator analyses were conducted to determine the potential influence of demographic and clinical factors (eg, medication exposure).

resultsIndependent of diagnosis, we found that neurocognitive impairments, and depressive, anxiety and negative symptoms, were significantly associated with functioning. The association of neurocognition with social and occupational functioning remained significant even when constraining for age (15-25-year-olds only) or diagnosis (affective disorders only) in the final model.

conclusionsThis study demonstrated that, in a clinically representative sample of youth, the key determinants of functioning may not be disorder specific. Further, evidence of neurocognitive dysfunction suggests that interventions that target cognition and functioning should not necessarily be reserved just for older adults with established illness.

Indexed as

Disability EvaluationAdolescentAdultAlcoholismAustraliaChildCohort StudiesCorrelation of DataCross-Sectional StudiesDevelopmental DisabilitiesFemaleHumansMaleMental DisordersMood DisordersNeurocognitive Disordersalcohol usefunctional impairmentmental illnessneurocognitionsymptom dimensionstransdiagnostic

Identifiers

PMID30567821
PMCPMC6303611

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.