Evidence map›Paper›PMID 30567738›Full record

ArticleThe Journal of biological chemistry2019

The catalytic mechanism of electron-bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD<sup/>.

Gerrit J Schut, Nishya Mohamed-Raseek, Monika Tokmina-Lukaszewska, David W Mulder, Diep M N Nguyen, Gina L Lipscomb, John P Hoben, Angela Patterson, Carolyn E Lubner, Paul W King and 4 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

  1. Biophysical journal · 2026
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  4. The Use of Dansyl Chloride to Probe Protein Structure and Dynamics.International journal of molecular sciences · 2025
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  16. An uncharacteristically low-potential flavin governs the energy landscape of electron bifurcation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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  18. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Gerrit J SchutFrom the Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602-7229.
Nishya Mohamed-Raseekthe Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506.
Monika Tokmina-Lukaszewskathe Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59717.
David W Mulderthe Biosciences Center, National Renewable Energy Laboratory, Golden, Colorado 80401, and.
Diep M N NguyenFrom the Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602-7229.
Gina L LipscombFrom the Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602-7229.
John P Hobenthe Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506.
Angela Pattersonthe Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59717.
Carolyn E Lubnerthe Biosciences Center, National Renewable Energy Laboratory, Golden, Colorado 80401, and.
Paul W Kingthe Biosciences Center, National Renewable Energy Laboratory, Golden, Colorado 80401, and.ORCID 0000-0001-5039-654X
John W Petersthe Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164.
Brian Bothnerthe Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59717.
Anne-Frances Millerthe Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506.ORCID 0000-0003-4973-2061
Michael W W AdamsFrom the Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602-7229, adamsm@uga.edu.ORCID 0000-0002-9796-5014
University of Georgia · USMontana State University · USNational Laboratory of the Rockies · USUniversity of Kentucky · USWashington State University · US

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Jeffrey Good · 2012 to 2026
$60.0M
NIGMS NIH HHS P20 GM103474
6 · The paper itself

Abstract

Electron bifurcation plays a key role in anaerobic energy metabolism, but it is a relatively new discovery, and only limited mechanistic information is available on the diverse enzymes that employ it. Herein, we focused on the bifurcating electron transfer flavoprotein (ETF) from the hyperthermophilic archaeon

Indexed as

BiocatalysisArchaeal ProteinsElectron-Transferring FlavoproteinsNADPyrobaculumArchaeal ProteinsElectron-Transferring FlavoproteinsNADanaerobic physiologyarchaeabifurcationbioenergeticscharge transferelectron paramagnetic resonance (EPR)electron transportEtfABCXextreme thermophileflavinflavoproteinradicalsemiquinone

Identifiers

PMID30567738
PMCPMC6398123
OpenAlexW2903827153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.