Evidence map›Paper›PMID 30567604›Full record

ArticleTrials2018

Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) randomized controlled trial.

Maude Perreault, Stephanie A Atkinson, Michelle F Mottola, Stuart M Phillips, Keyna Bracken, Eileen K Hutton, Feng Xie, David Meyre, Rita E Morassut, Harry Prapavessis and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01689961 (Be Healthy in Pregnancy), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01689961 nacompletednot on this map

Be Healthy in Pregnancy (BHIP) With Nutrition and Exercise

TypeinterventionalSponsorMcMaster UniversityRan2012 to 2019Enrolled242ConditionsPregnancy Complications, Weight GainArmsStructured + monitored nutrition and exercise intervention
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Maude PerreaultDepartment Pediatrics, HSC 3A44, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4K1, Canada.
Stephanie A AtkinsonDepartment Pediatrics, HSC 3A44, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4K1, Canada. satkins@mcmaster.ca.ORCID http://orcid.org/0000-0002-5680-7546
Michelle F MottolaSchool of Kinesiology, Western University, London, ON, Canada.
Stuart M PhillipsDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Keyna BrackenDepartment of Family Medicine, McMaster University, Hamilton, ON, Canada.
Eileen K HuttonDepartment of Obstetrics & Gynecology, McMaster University, Hamilton, ON, Canada.
Feng XieDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
David MeyreDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Rita E MorassutDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Harry PrapavessisSchool of Kinesiology, Western University, London, ON, Canada.
Lehana ThabaneDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
BHIP Study team
Impact · CAMcMaster University · CAWestern University · CA

Funding

Canadian Institutes of Health Research FRN 123347Dairy Research Cluster Initiative AIP-CL04
6 · The paper itself

Abstract

backgroundEvidence from epidemiological and animal studies support the concept of programming fetal, neonatal, and adult health in response to in utero exposures such as maternal obesity and lifestyle variables. Excess gestational weight gain (GWG), maternal physical activity, and sub-optimal and excess nutrition during pregnancy may program the offspring's risk of obesity. Maternal intake of dairy foods rich in high-quality proteins, calcium, and vitamin D may influence later bone health status. Current clinical practice guidelines for managing GWG are not founded on randomized trials and lack specific "active intervention ingredients." The Be Healthy in Pregnancy (BHIP) study is a randomized controlled trial (RCT) designed to test the effectiveness of a novel structured and monitored Nutrition + Exercise intervention in pregnant women of all pre-pregnancy weight categories (except extreme obesity), delivered through prenatal care in community settings (rather than in hospital settings), on the likelihood of women achieving recommended GWG and a benefit to bone status of offspring and mother at birth and six months postpartum.

methodsThe BHIP study is a two-site RCT that will recruit up to 242 participants aged > 18 years at 12-17 weeks of gestation. After baseline measures, participants are randomized to either a structured and monitored Nutrition + Exercise (intervention) or usual care (control) program for the duration of their pregnancy. The primary outcome of the study is the percent of women who achieve GWG within the Institute of Medicine (IOM) guidelines. The secondary outcomes include: (1) maternal bone status via blood bone biomarkers during pregnancy; (2) infant bone status in cord blood; (3) mother and infant bone status measured by dual-energy absorptiometry scanning (DXA scan) at six months postpartum; (4) other measures including maternal blood pressure, blood glucose and lipid profiles, % body fat, and postpartum weight retention; and (5) infant weight z-scores and fat mass at six months of age. DISCUSSION: If effective, this RCT will generate high-quality evidence to refine the nutrition guidelines during pregnancy to improve the likelihood of women achieving recommended GWG. It will also demonstrate the importance of early nutrition on bone health in the offspring.

trial registrationClinicalTrials.gov, NCT01689961 Registered on 21 September 2012.

Indexed as

Diet, HealthyExerciseAge FactorsBone DensityCommunity Health ServicesDairy ProductsFemaleHumansInfantInfant, NewbornMaternal Nutritional Physiological PhenomenaMulticenter Studies as TopicNutritional StatusNutritive ValueOntarioPregnancyBoneDairy foodsDevelopmental origins of health and diseaseExerciseGestational weight gainInfancyNutritionPregnancyProteinsRandomized controlled trial

Identifiers

PMID30567604
PMCPMC6299965
OpenAlexW2904248541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.