ArticleJournal of translational medicine2018
Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery.
Article in Journal of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01730365 (Discrimination of Benign and Malignant Human Tissue During Percutaneous Interventions Using Optical Spectroscopy Techniques), which is not on this map. Cited by 36 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Discrimination of Benign and Malignant Human Tissue During Percutaneous Interventions Using Optical Spectroscopy Techniques
Who cites it
36 citing papers in PubMed, 80 citations in OpenAlex.
- Article
- Translational photoacoustic and ultrasound imaging catheter for characterizing gastrointestinal inflammation and fibrosis: a study with a pig modelBiomedical optics express · 2026Article
- Diffuse reflectance spectroscopy for enhanced diagnostic precision in breast cancer.Journal of translational medicine · 2025Article
- A Comprehensive Review of Margin Identification Methods in Soft Tissue Sarcoma.Current oncology (Toronto, Ont.) · 2025Review
- Real-time peri-operative microcalcification detection in superficial breast tissues.Scientific reports · 2025Article
- Toward handheld optically guided biopsy combining diffuse reflectance spectroscopy and autofluorescence.Journal of biomedical optics · 2025Article
- Optical sensor for fast and accurate lung cancer detection with tissue autofluorescence and diffuse reflectance spectroscopy.Thoracic cancer · 2025Article
- Camera-on-tip endoscope forBiomedical optics express · 2025Article
- Deformable multi-modal image registration for the correlation between optical measurements and histology images.Journal of biomedical optics · 2024Article
- Margin assessment during breast conserving surgery using diffuse reflectance spectroscopy.Journal of biomedical optics · 2024Article
- Point Projection Mapping System for Tracking, Registering, Labeling, and Validating Optical Tissue Measurements.Journal of imaging · 2024Article
- Extended-wavelength diffuse reflectance spectroscopy dataset of animal tissues for bone-related biomedical applications.Scientific data · 2024Article
- Reflectance spectroscopy: a non-invasive strategy to explore skin reactions to topical products.Frontiers in chemistry · 2024Review
- Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review.Sensors (Basel, Switzerland) · 2023Review
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy.Biomedical optics express · 2023Article
- Diffuse reflectance spectroscopy for accurate margin assessment in breast-conserving surgeries: importance of an optimal number of fibers.Biomedical optics express · 2023Article
- Microcamera Visualisation System to Overcome Specular Reflections for Tissue Imaging.Micromachines · 2023Article
- Overview of Optical Biosensors for Early Cancer Detection: Fundamentals, Applications and Future Perspectives.Biology · 2023Review
- Public health implications of computer-aided diagnosis and treatment technologies in breast cancer care.AIMS public health · 2023Review
- Diffuse reflectance spectroscopy sensor to differentiate between glial tumor and healthy brain tissue: a proof-of-concept study.Biomedical optics express · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast cancer surgeons struggle with differentiating healthy tissue from cancer at the resection margin during surgery. We report on the feasibility of using diffuse reflectance spectroscopy (DRS) for real-time in vivo tissue characterization.
methodsEvaluating feasibility of the technology requires a setting in which measurements, imaging and pathology have the best possible correlation. For this purpose an optical biopsy needle was used that had integrated optical fibers at the tip of the needle. This approach enabled the best possible correlation between optical measurement volume and tissue histology. With this optical biopsy needle we acquired real-time DRS data of normal tissue and tumor tissue in 27 patients that underwent an ultrasound guided breast biopsy procedure. Five additional patients were measured in continuous mode in which we obtained DRS measurements along the entire biopsy needle trajectory. We developed and compared three different support vector machine based classification models to classify the DRS measurements.
resultsWith DRS malignant tissue could be discriminated from healthy tissue. The classification model that was based on eight selected wavelengths had the highest accuracy and Matthews Correlation Coefficient (MCC) of 0.93 and 0.87, respectively. In three patients that were measured in continuous mode and had malignant tissue in their biopsy specimen, a clear transition was seen in the classified DRS measurements going from healthy tissue to tumor tissue. This transition was not seen in the other two continuously measured patients that had benign tissue in their biopsy specimen.
conclusionsIt was concluded that DRS is feasible for integration in a surgical tool that could assist the breast surgeon in detecting positive resection margins during breast surgery. Trail registration NIH US National Library of Medicine-clinicaltrails.gov, NCT01730365. Registered: 10/04/2012 https://clinicaltrials.gov/ct2/show/study/NCT01730365.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.