Evidence map›Paper›PMID 30567481›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2019

CD36 Enhances Vascular Smooth Muscle Cell Proliferation and Development of Neointimal Hyperplasia.

Hong Yue, Maria Febbraio, Philip A Klenotic, David J Kennedy, Yueheng Wu, Shaoxian Chen, Amira F Gohara, Oliver Li, Adam Belcher, Bin Kuang and 3 more

Open access · greenAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  6. Article
  7. TSP-1, TSP-2, and TSP-5 demonstrate sexual dimorphism in intimal hyperplasia in rats and mice.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  8. Article
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  12. Matricellular proteins in atherosclerosis development.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Review
  13. Article
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  17. Review
  18. Article
  19. Research advance of Nrf2 on atherosclerosis by regulating vascular smooth muscle cell.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Hong YueFrom the Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV (H.Y., A.B., W.L.).
Maria FebbraioDepartment of Dentistry, University of Alberta, Edmonton, Canada (M.F.).
Philip A KlenoticCase Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH (P.A.K.).
David J KennedyDepartment of Medicine (D.J.K.), University of Toledo, OH.
Yueheng WuGuangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, China (Y.W., S.C.).
Shaoxian ChenGuangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, China (Y.W., S.C.).
Amira F GoharaDepartment of Pathology (A.F.G.), University of Toledo, OH.
Oliver LiMarshall University Marshall Institute for Interdisciplinary Research, Huntington, WV (O.L., W.L.).
Adam BelcherFrom the Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV (H.Y., A.B., W.L.).
Bin KuangDepartment of Plastic and Peripheral Vascular Surgery, Guangdong General Hospital, China (B.K.).
Thomas M McIntyreDepartments of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, OH (T.M.M.).
Roy L SilversteinDepartment of Medicine, Medical College of Wisconsin, Milwaukee (R.L.S.).
Wei LiFrom the Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine, Huntington, WV (H.Y., A.B., W.L.).
Marshall University · USGuangdong General Hospital · CNUniversity of Toledo · USCleveland Clinic Lerner College of Medicine · USGuangdong Academy of Medical Sciences · CNUniversity Hospitals Case Medical Center · USUniversity of Alberta · CA

Funding

WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
ROLE OF MICROPARTICLES IN THE ANTI-PHOSPHOLIPID SYNDROMEP50HL081011 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MCINTYRE, THOMAS · 2006 to 2010
$12.9M
ERK5 and CD36 link oxidative stress to platelet dysfunction and ischemic injuryR01HL142152 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MORRELL, CRAIG N, SILVERSTEIN, ROY L · 2019 to 2022
$2.5M
Circulating Age-related Lipid Mediators in ThrombosisR01HL092747 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MCINTYRE, THOMAS M · 2007 to 2010
$2.2M
Systemic Oxidized Phospholipids in Mitochondrial Dysfunction of Alcoholic InjuryR01AA017748 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI MCINTYRE, THOMAS M · 2008 to 2012
$1.9M
Counter regulatory mechanisms of cardiotonic steroids in cardio-renal syndromeR01HL137004 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI KENNEDY, DAVID JOSEPH · 2017 to 2021
$1.9M
Platelet-inspired Delivery System for Targeted Thrombolytic TherapyR01HL129179 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI SEN GUPTA, ANIRBAN · 2015 to 2018
$1.8M
Dynamic regulation of thrombosis by the platelet proteomeR01HL130090 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MCINTYRE, THOMAS M · 2016 to 2019
$1.6M
NHLBI NIH HHS P50 HL081011NHLBI NIH HHS R01 HL092747NHLBI NIH HHS R01 HL129179NHLBI NIH HHS R01 HL130090NHLBI NIH HHS R01 HL137004NHLBI NIH HHS R01 HL142152NIAAA NIH HHS R01 AA017748NIGMS NIH HHS P20 GM103434
6 · The paper itself

Abstract

Objective- Dysregulated proliferation of vascular smooth muscle cells (VSMC) plays an essential role in neointimal hyperplasia. CD36 functions critically in atherogenesis and thrombosis. We hypothesize that CD36 regulates VSMC proliferation and contributes to the development of obstructive vascular diseases. Approach and Results- We found by immunofluorescent staining that CD36 was highly expressed in human vessels with obstructive diseases. Using guidewire-induced carotid artery injury and shear stress-induced intima thickening models, we compared neointimal hyperplasia in Apoe

Indexed as

AnimalsCD36 AntigensCell ProliferationCyclin AHyperplasiaMaleMiceMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaSTAT3 Transcription FactorCD36 AntigensCyclin AStat3 protein, mouseSTAT3 Transcription Factorcyclin Ahyperplasiamiceneointimathrombosis

Identifiers

PMID30567481
PMCPMC6345504
OpenAlexW2906384245

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.