ArticleGenes2018
Fragmented Nuclear DNA is the Predominant Genetic Material in Human Hair Shafts.
Article in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- Developmental validation of a six-dye Multi-InDels kit for personal identification and paternity testing of highly degraded DNA samples.International journal of legal medicine · 2026Article
- Developmental validation of the rapidpuncher, an automated laser-based sampling system that eliminates cross-contamination in the forensic analysis of FTA cards.International journal of legal medicine · 2026Article
- Precision ID mtDNA Whole Genome Panel and sequencing of telogen hairs - perspectives for validation and implementation in casework.International journal of legal medicine · 2026Article
- Article
- Individual identification and kinship testing from hair shaft nuclear DNA: leveraging short amplicon strategy and bioinformatics models.International journal of legal medicine · 2026Article
- Rootless hair as a reliable source of forensic genetic information.Genome biology · 2026Article
- Human hair as a diagnostic tool in medicine.Biochemistry and biophysics reports · 2025Review
- From One Strand Dyed/Undyed Hair With/Without Root to Fast and Successful STR Profiling and Evaluation With Principle Component Analysis.Electrophoresis · 2025Article
- Unlocking the Potential of Animal Hair Shafts for Genomic Studies: A Comprehensive Evaluation of DNA Quality.Biology · 2025Article
- A partially automated method for DNA extraction from marmoset hair follicles to avoid blood chimerism.Frontiers in genetics · 2025Article
- Review: Computational analysis of human skeletal remains in ancient DNA and forensic genetics.iScience · 2023Review
- Record-matching of STR profiles with fragmentary genomic SNP data.European journal of human genetics : EJHG · 2023Article
- A method to generate capture baits for targeted sequencing.Nucleic acids research · 2023Article
- DNA and protein analyses of hair in forensic genetics.International journal of legal medicine · 2023Review
- Article
- Detection of deletion/insertion polymorphism profiles from single human hair shafts.Molecular biology reports · 2022Article
- Article
- Evidence for multi-copy Mega-NUMTs in the human genome.Nucleic acids research · 2021Article
- Interpol review of forensic biology and forensic DNA typing 2016-2019.Forensic science international. Synergy · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While shed hairs are one of the most commonly encountered evidence types, they are among the most limited in terms of DNA quantity and quality. As a result, nuclear DNA short tandem repeat (STR) profiling is generally unsuccessful and DNA testing of shed hair is instead performed by targeting the mitochondrial DNA control region. Although the high copy number of mitochondrial DNA relative to nuclear DNA routinely permits the recovery of mitochondrial DNA (mtDNA) data in these cases, mtDNA profiles do not offer the discriminatory power of nuclear DNA profiles. In order to better understand the total content and degradation state of DNA in single shed hairs and assess the feasibility of recovering highly discriminatory nuclear DNA data from this common evidence type, high throughput shotgun sequencing was performed on both recently collected and aged (approximately 50-year-old) hair samples. The data reflect trends that have been demonstrated previously with other technologies, namely that mtDNA quantity and quality decrease along the length of the hair shaft. In addition, the shotgun data reveal that nuclear DNA is present in shed hair and surprisingly abundant relative to mitochondrial DNA, even in the most distal fragments. Nuclear DNA comprised, at minimum, 88% of the total human reads in any given sample, and generally more than 95%. Here, we characterize both the nuclear and mitochondrial DNA content of shed hairs and discuss the implications of these data for forensic investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.