Evidence map›Paper›PMID 30567296›Full record

ArticleNutrients2018

Predictivity of Autoimmune Stigmata for Gluten Sensitivity in Subjects with Microscopic Enteritis: A Retrospective Study.

Giuseppe Losurdo, Mariabeatrice Principi, Andrea Iannone, Antonio Giangaspero, Domenico Piscitelli, Enzo Ierardi, Alfredo Di Leo, Michele Barone

2 registry-linked trialsAbstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04077840 completednot on this map

Autoimmune Diseases and Serum Autoantibodies in Non-celiac Wheat Sensitivity Patients in Comparison to IBS Patients

TypeobservationalSponsorUniversity of PalermoRan2016 to 2018Enrolled58ConditionsNon-celiac Gluten Sensitivity, Non-celiac Wheat Sensitivity
NCT04219813 narecruitingnot on this mapstarted 2021, after this paper: background citation

Urinary Gluten Detection in Patients With Non-celiac Gluten/Wheat Sensitivity

TypeinterventionalSponsorUniversity of PalermoRan2021 to 2026Enrolled40ConditionsNon-celiac Gluten/Wheat SensitivityArmsUrinary test
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Observational
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giuseppe LosurdoSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari (Italy), Piazza G. Cesare 11, 70124 Bari, Italy. giuseppelos@alice.it.ORCID 0000-0001-7038-3287
Mariabeatrice PrincipiSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari (Italy), Piazza G. Cesare 11, 70124 Bari, Italy. b.principi@gmail.com.
Andrea IannoneSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari (Italy), Piazza G. Cesare 11, 70124 Bari, Italy. ianan@hotmail.it.
Antonio GiangasperoSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari (Italy), Piazza G. Cesare 11, 70124 Bari, Italy. antoniogiangaspero@libero.it.
Domenico PiscitelliSection of Pathology, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy. domenico.piscitelli@uniba.it.
Enzo IerardiSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari (Italy), Piazza G. Cesare 11, 70124 Bari, Italy. ierardi.enzo@gmail.com.
Alfredo Di LeoSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari (Italy), Piazza G. Cesare 11, 70124 Bari, Italy. alfredo.dileo@uniba.it.
Michele BaroneSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari (Italy), Piazza G. Cesare 11, 70124 Bari, Italy. michele.barone@uniba.it.ORCID 0000-0001-8284-5127

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-celiac gluten sensitivity (NCGS) is an emerging gluten-related condition. We investigated whether the presence of autoimmune stigmata in a group of patients with clinical suspicion of NCGS and a histological picture of microscopic enteritis (ME) could be a predictive factor of NCGS. Patients with ME were followed up by periodical examinations. At baseline, we collected data about previous clinical history, including autoimmune diseases. NCGS was diagnosed according to Salerno criteria; other causes of ME were diagnosed according to well-established protocols. Patients with celiac disease were excluded. Student's and chi-square tests were used in univariate analysis. Kaplan-Meier curves and Cox regression were used to estimate hazard ratios (HR). Sixty-three patients were included. Twenty-two had a final diagnosis of NCGS; the remaining 41 had non-gluten-related causes of ME. Prevalence of autoimmune thyroiditis was higher among NCGS patients (40.1%) than in other ME (14.6%;

Indexed as

AdultAutoimmune DiseasesEnteritisFemaleFood HypersensitivityGliadinGlutensHumansKaplan-Meier EstimateMalabsorption SyndromesMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesThyroiditis, AutoimmuneYoung AdultGliadinGlutensanti-gliadinanti-nucleus antibodyautoimmunitygluten sensitivitythyroiditis

Identifiers

PMID30567296
PMCPMC6315522

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.