Evidence map›Paper›PMID 30567242›Full record

ArticleBMJ case reports2018

Metastatic lung adenocarcinoma- associated thrombotic microangiopathy in a renal transplant recipient.

Eswari Vilayur, Jillian de Malmanche, Paul Trevillian, David Ferreira

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Eswari VilayurSchool of Epidemiology and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.
Jillian de MalmancheHaematology Department, Calvary Mater Hospital, Newcastle, New South Wales, Australia.
Paul TrevillianSchool of Epidemiology and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.
David FerreiraMedical Department, Liverpool Hospital, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-3142-4503
John Hunter Hospital · AUCalvary Mater Newcastle Hospital · AULiverpool Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombotic microangiopathy (TMA) after renal transplantation can be a diagnostic challenge. TMA can occur with calcineurin inhibitors, allograft rejection, infection, mutations in complement regulatory proteins and autoimmunity. A 52-year-old male renal transplant recipient presented with extensive deep vein thrombosis. He developed transfusion-dependent microangiopathic haemolytic anaemia with thrombocytopenia. He did not respond calcineurin inhibitor cessation, eculizumab or plasma exchange. ADAMTS13 and complement levels were normal. Infection and autoimmune screens were negative. A diagnosis of metastatic adenocarcinoma was made on bone marrow biopsy. This represents a rare case of malignancy-associated TMA in a renal transplant recipient. Early diagnosis can facilitate the prompt initiation of chemotherapy which is the only treatment option.

Indexed as

Adenocarcinoma of LungHumansKidney TransplantationLung NeoplasmsMaleMiddle AgedNeoplasm MetastasisPostoperative ComplicationsThrombotic Microangiopathiesacute renal failurehaematology (incl blood transfusion)renal transplantationrespiratory cancer

Identifiers

PMID30567242
PMCPMC6301462
OpenAlexW2903634429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.