Evidence map›Paper›PMID 30567158›Full record

ArticleBMJ case reports2018

Atypical presentation of progressive young onset dementia.

Bushra Elhusein, Ahmed Radwan, Abdalla Khairi, Mohamed Ahmed

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bushra ElhuseinMental Health Services, Department of Medical Education, Hamad Medical Corporation, Doha, Qatar.
Ahmed RadwanMental Health Services, Department of Medical Education, Hamad Medical Corporation, Doha, Qatar.ORCID http://orcid.org/0000-0002-1178-1258
Abdalla KhairiMental Health Services, Department of Medical Education, Hamad Medical Corporation, Doha, Qatar.
Mohamed AhmedMental Health Services, Department of Medical Education, Hamad Medical Corporation, Doha, Qatar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the case of a 34-year-old Jordanian woman who was referred to mainstream mental health services because of irritability, agitation, loss of appetite, withdrawal from family activities and sleeping difficulties. She was initially diagnosed with major depressive disorder but subsequently showed very poor response to antidepressant therapy. Her presentation gradually and dramatically progressed into full blown dementia within couple of years. Brain MRI showed atrophic cortical changes and subcortical white matter alterations consistent with Alzheimer's dementia. Brain PET scan revealed reduction in cerebral glucose metabolism in temporoparietal areas bilaterally most consistent with Alzheimer's dementia. There was a strong family history of early-onset dementia. A final diagnosis of young onset dementia was made, and unfortunately, she passed away at the age of 44 years.

Indexed as

AdultAlzheimer DiseaseDiagnosis, DifferentialFatal OutcomeFemaleGenetic Predisposition to DiseaseHumansMagnetic Resonance ImagingMajor Depressive DisorderPositron-Emission TomographySeverity of Illness Indexdementia, alzheimer’s typedepressive disorderdisability

Identifiers

PMID30567158
PMCPMC6301643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.