Evidence map›Paper›PMID 30566939›Full record

ReviewJournal of innate immunity2019

Functions of the Microbiota for the Physiology of Animal Metaorganisms.

Daniela Esser, Janina Lange, Georgios Marinos, Michael Sieber, Lena Best, Daniela Prasse, Jay Bathia, Malte C Rühlemann, Kathrin Boersch, Cornelia Jaspers and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of innate immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.

  1. A systematic review of the microbial community in taiassuids: a One Health approach.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The gut microbiota in thrombosis.Nature reviews. Cardiology · 2025
    Review
  8. Article
  9. Article
  10. ThemBio · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Animal Microbiomes as a Source of Novel Antibiotic-Producing Strains.International journal of molecular sciences · 2023
    Review
  19. Article
  20. Host-microbiome interaction in fish and shellfish: An overview.Fish and shellfish immunology reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Daniela EsserInstitute of Experimental Medicine, Christian Albrecht University Kiel, Kiel, Germany.
Janina LangeZoological Institute, Christian Albrecht University Kiel, Kiel, Germany.
Georgios MarinosInstitute of Experimental Medicine, Christian Albrecht University Kiel, Kiel, Germany.
Michael SieberDepartment of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Lena BestInstitute of Experimental Medicine, Christian Albrecht University Kiel, Kiel, Germany.
Daniela PrasseInstitute of General Microbiology, Christian Albrecht University Kiel, Kiel, Germany.
Jay BathiaZoological Institute, Christian Albrecht University Kiel, Kiel, Germany.
Malte C RühlemannInstitute of Clinical Molecular Biology, Christian Albrecht University Kiel, Kiel, Germany.
Kathrin BoerschInstitute of Clinical Molecular Biology, Christian Albrecht University Kiel, Kiel, Germany.
Cornelia JaspersEvolutionary Ecology of Marine Fishes, GEOMAR - Helmholtz Center for Ocean Research, Kiel, Germany.
Felix SommerInstitute of Clinical Molecular Biology, Christian Albrecht University Kiel, Kiel, Germany, f.sommer@ikmb.uni-kiel.de.
Christian-Albrechts-Universität zu Kiel · DEGEOMAR Helmholtz Centre for Ocean Research Kiel · DEMax Planck Institute for Evolutionary Biology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Animals are usually regarded as independent entities within their respective environments. However, within an organism, eukaryotes and prokaryotes interact dynamically to form the so-called metaorganism or holobiont, where each partner fulfils its versatile and crucial role. This review focuses on the interplay between microorganisms and multicellular eukaryotes in the context of host physiology, in particular aging and mucus-associated crosstalk. In addition to the interactions between bacteria and the host, we highlight the importance of viruses and nonmodel organisms. Moreover, we discuss current culturing and computational methodologies that allow a deeper understanding of underlying mechanisms controlling the physiology of metaorganisms.

Indexed as

AgingAnimalsComputational BiologyHealth StatusHost Microbial InteractionsHumansMicrobiotaModels, BiologicalMucusSymbiosisHostMetaorganismMicrobiomeMicrobiotaPhysiology

Identifiers

PMID30566939
PMCPMC6738199
OpenAlexW2903733115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.