Evidence map›Paper›PMID 30566885›Full record

ArticleImmunity2018

Sparks Fly in PGE2-Modulated Macrophage Polarization.

Fabien Franco, Mathias Wenes, Ping-Chih Ho

Abstract readComment
PubMed Publisher
In one paragraph

Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Progress in macrophage immune regulation of atherosclerosis.American journal of translational research · 2025
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Fabien FrancoDepartment of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Cancer Research, University of Lausanne, Epalinges, Switzerland.
Mathias WenesDepartment of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Cancer Research, University of Lausanne, Epalinges, Switzerland.
Ping-Chih HoDepartment of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Cancer Research, University of Lausanne, Epalinges, Switzerland. Electronic address: ping-chih.ho@unil.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How macrophages convey extracellular signals by bridging metabolism and functions remains unclear. In this issue of Immunity, Sanin et al. (2018) report that prostaglandin E2 (PGE2) treatment in interleukin-4-activated macrophages suppresses mitochondrial membrane potential to control voltage-regulated genes involved in proliferation and immune responses.

Indexed as

DinoprostoneMacrophagesGene ExpressionMembrane Potential, MitochondrialDinoprostone

Identifiers

PMID30566885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.