ArticleImmunity2018
Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.
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Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
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Who cites it
65 citing papers in PubMed, 103 citations in OpenAlex.
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- Macrophage FOLR2 drives liver fibrosis via intercellular engagement of TGFβRII.Acta pharmacologica Sinica · 2026Article
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- Metabolic regulation of tumor-associated macrophage function and immunotherapy in cancer.Cancer biology & medicine · 2026Review
- SIRT3 activation protects from nabumetone-induced mitochondrial toxicity in adult human cardiomyocytes.Cellular and molecular life sciences : CMLS · 2026Article
- A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages.Immunity · 2026Article
- Clusterzymes-driven therapy: ultrasmall CuJournal of nanobiotechnology · 2026Article
- IgA2 ACPA Drives a Hyper-Inflammatory Phenotype in Macrophages via ATP Synthase and COX2.European journal of immunology · 2025Article
- Synergistic Antitumor Immunotherapy via Mitochondria Regulation in Macrophages and Tumor Cells by an Iridium Photosensitizer.ACS central science · 2025Article
- From silent partners to potential therapeutic targets: macrophages in colorectal cancer.Cancer immunology, immunotherapy : CII · 2025Review
- Immunometabolic reprogramming in macrophages infected with active and dormantInfection and immunity · 2025Article
- Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion.Cell communication and signaling : CCS · 2025Review
- Metabolic adaptations of ILC2 and Th2 cells in type 2 immunity.Current opinion in immunology · 2024Review
- TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis.Current medical science · 2024Article
- Spinster homolog 2/S1P signaling ameliorates macrophage inflammatory response to bacterial infections by balancing PGECell communication and signaling : CCS · 2024Article
- The S341P mutant MYOC renders the trabecular meshwork sensitive to cyclic mechanical stretch.Heliyon · 2024Article
- Monocyte-macrophages modulate intestinal homeostasis in inflammatory bowel disease.Biomarker research · 2024Review
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5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 4 institutions in 3 countries.
David E SaninDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Mai MatsushitaDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Ramon I Klein GeltinkDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Katarzyna M GrzesDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Nikki van Teijlingen BakkerDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany; Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany.
Mauro CorradoDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Agnieszka M KabatDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Michael D BuckDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Jing QiuDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Simon J LawlessDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Alanna M CameronDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Matteo VillaDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Francesc BaixauliDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Annette E PattersonDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Fabian HässlerDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Jonathan D CurtisDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Christina M O'NeillDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
David O'SullivanDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Duojiao WuZhongshan Hospital, Fudan University, Shanghai 200032, China.
Gerhard MittlerProteomics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Stanley Ching-Cheng HuangDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Erika L PearceDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.
Edward J PearceDepartment of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany; Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany. Electronic address: pearceed@ie-freiburg.mpg.de.
Max Planck Institute of Immunobiology and Epigenetics · DEWashington University in St. Louis · USFudan University · CNUniversity of Freiburg · DE
Funding
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1MDendritic Cell Function in SchistosomiasisR01AI053825 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI PEARCE, EDWARD J. · 2002 to 2010
$3.4MMACROPHAGE FATTY ACID METABOLISM IN IMMUNITY TO HELMINTHSR01AI110481 · NIAID · WASHINGTON UNIVERSITY · PI PEARCE, EDWARD J. · 2015 to 2019
$1.5MTUMOR-IMPOSED GLUCOSE RESTRICTIONS ON T CELLS DAMPEN IMMUNITYR01CA181125 · NCI · WASHINGTON UNIVERSITY · PI PEARCE, ERIKA L · 2014 to 2017
$989kNCI NIH HHS R01 CA181125NIAID NIH HHS R01 AI053825NIAID NIH HHS R01 AI110481
Abstract
Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψ
Indexed as
AnimalsCell NucleusCells, CulturedDinoprostoneDNA-Binding ProteinsGene Expression ProfilingGene Expression RegulationHEK293 CellsHumansInterleukin-4Macrophage ActivationMacrophagesMembrane Potential, MitochondrialMiceMice, Inbred C57BLNIH 3T3 CellsDinoprostoneDNA-Binding ProteinsEtv1 protein, mouseInterleukin-4Transcription FactorsETS variant 1ETV1IL-4immunometabolisminterleukin-4macrophagemalate-aspartate shuttlemitochondriamitochondrial membrane potentialPGE2proliferationprostaglandin E2RELMα
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.