Evidence map›Paper›PMID 30566713›Full record

ArticleOphthalmic surgery, lasers & imaging retina2018

Fibrin Glue and Internal Limiting Membrane Abrasion for Optic Disc Pit Maculopathy.

David R P Almeida, Eric K Chin, Parnian Arjmand, Gabriel Velez, Lucy P Evans, Vinit B Mahajan

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PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmic surgery, lasers & imaging retina, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David R P Almeida
Eric K Chin
Parnian Arjmand
Gabriel Velez
Lucy P Evans
Vinit B Mahajan

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Yang Hu · 2017 to 2026
$8.0M
Gene Silencing and Gene Editing in PhototransductionR01EY024698 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stephen H Tsang · 2015 to 2026
$4.7M
Structure and Function of Calpain-5R01EY024665 · NEI · UNIVERSITY OF IOWA · PI MAHAJAN, VINIT B · 2015 to 2019
$1.9M
Mechanistic Studies on Regenerative Medicine Approaches to Childhood BlindnessR01EY026682 · NEI · UNIVERSITY OF IOWA · PI BASSUK, ALEXANDER G, MAHAJAN, VINIT B · 2016 to 2019
$1.6M
Mechanism-based therapies for photoreceptor degenerationR01EY025225 · NEI · UNIVERSITY OF IOWA · PI MAHAJAN, VINIT B · 2015 to 2018
$1.3M
Molecular Genetics of Dominant Neovascular Inflammatory VitreoretinopathyK08EY020530 · NEI · UNIVERSITY OF IOWA · PI MAHAJAN, VINIT B · 2011 to 2015
$1.1M
Evaluating GWAS AMD Candidate Loci by Gene Editing in Human iPS CellsR21AG050437 · NIA · UNIVERSITY OF IOWA · PI BASSUK, ALEXANDER G, MAHAJAN, VINIT B · 2015 to 2016
$431k
NEI NIH HHS K08 EY020530NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY024665NEI NIH HHS R01 EY024698NEI NIH HHS R01 EY025225NEI NIH HHS R01 EY026682NIA NIH HHS R21 AG050437NIGMS NIH HHS T32 GM007337NIH HHS K08EY020530NIH HHS P30EY026877NIH HHS R01EY024665NIH HHS R01EY024698NIH HHS R01EY025225NIH HHS R01EY026682NIH HHS R21AG050437NIH HHS T32GM007337
6 · The paper itself

Abstract

BACKGROUND AND

objectiveTo describe a novel surgical technique using pars plana vitrectomy (PPV), internal limiting membrane (ILM) abrasion, and intravitreal fibrin glue for the treatment of optic disc pit maculopathy. PATIENTS AND

methodsSurgical case series technique with scanning electron microscopy (SEM) of human post-mortem eyes.

resultsUsing SEM, the authors demonstrate the persistent adherence of vitreous fragments to the optic disc following induction of posterior vitreous detachment in human postmortem eyes. The authors describe a surgical technique using PPV, Tano Diamond Dusted Membrane Scraper for an ILM abrasion, intravitreal fibrin glue (Tisseel), and gas-air exchange to seal optic disc pits. The authors report successful long-term visual and anatomical outcomes in three patients.

conclusionsIntravitreal fibrin glue, when combined with ILM abrasion, may be a viable treatment option for optic disc pit maculopathy with good short- and long-term visual acuity outcomes. SEM shows that ILM abrasion removes vitreous fragments, which are persistently adherent and may lead to failure with other interventional techniques. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:e271-e277.].

Indexed as

Visual AcuityAdolescentAdultBasement MembraneEndotamponadeEye AbnormalitiesFemaleFibrin Tissue AdhesiveHumansLaser CoagulationMaleMiddle AgedOptic DiskTissue AdhesivesTomography, Optical CoherenceVitrectomyFibrin Tissue AdhesiveTissue Adhesives

Identifiers

PMID30566713
PMCPMC10887125
OpenAlexW2904179163

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.