Trial reportThe Journal of clinical endocrinology and metabolism2019
Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H2O Metabolism Pilot Study.
Trial report in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 59 citations in OpenAlex.
- Investigation of possible underlying mechanisms behind water-induced glucose reduction in adults with high copeptin.Scientific reports · 2021Trial
- Validity of different copeptin assays in the differential diagnosis of the polyuria-polydipsia syndrome.Scientific reports · 2021Trial
- Trial
- Serum sodium, tonicity, and risk of dementia in cohort and healthcare populations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The Association Between Outdoor Temperature During the Past Weeks and Current Fluid Homeostasis.Epidemiology (Cambridge, Mass.) · 2026Article
- Evaluation of serum and cerebrospinal fluid copeptin as biomarkers in children with febrile seizures, febrile illness without seizures, and meningitis: an exploratory study.BMC pediatrics · 2026Article
- Nutritional intervention improved dietary intake among patients receiving methadone maintenance treatment.Drug and alcohol dependence reports · 2026Article
- Water intake, hydration, and weight management: the glass is half-full!Physiology & behavior · 2025Review
- The Impact of Hydration on Metabolic Outcomes: From Arginine-Vasopressin Signaling to Clinical Implications.Medicina (Kaunas, Lithuania) · 2025Review
- Apparently healthy young black adults report lower total fluid intake and exhibit higher plasma copeptin than young White adults.Nutrition research (New York, N.Y.) · 2025Article
- Relationship between fluid intake, hydration status and cortisol dynamics in healthy, young adult males.Comprehensive psychoneuroendocrinology · 2025Article
- Inflammation and vasopressin hypersecretion in aging.Frontiers in endocrinology · 2025Review
- Association between Urine Specific Gravity as a Measure of Hydration Status and Risk of Type 2 Diabetes: The Kailuan Prospective Cohort Study.Nutrients · 2024Article
- Long-term health outcomes associated with hydration status.Nature reviews. Nephrology · 2024Review
- The possible role of the vasopressin system in hematopoiesis.Scientific reports · 2024Article
- The association between water intake and future cardiometabolic disease outcomes in the Malmö Diet and Cancer cardiovascular cohort.PloS one · 2024Article
- The association of copeptin with metabolic risk markers is modified by region of origin.Scientific reports · 2023Article
- Cross-sectional analysis of racial differences in hydration and neighborhood deprivation in young adults.The American journal of clinical nutrition · 2023Article
- Short-term association between outdoor temperature and the hydration-marker copeptin: a pooled analysis in five cohorts.EBioMedicine · 2023Article
- Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study.Antioxidants (Basel, Switzerland) · 2023Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBecause elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose. DESIGN, SETTING, AND
participantsThirty-one healthy adults with high copeptin (>10.7 pmol · L-1 in men and >6.1 pmol·L-1 in women) identified in a population-based survey from 2013 to 2015 and with a current 24-hour urine osmolality of >600 mOsm · kg-1 were included.
interventionAddition of 1.5 L water daily on top of habitual fluid intake for 6 weeks.
main outcome measurePre- and postintervention fasting plasma copeptin concentrations.
resultsReported mean water intake increased from 0.43 to 1.35 L · d-1 (P < 0.001), with no other observed changes in diet. Median (interquartile range) urine osmolality was reduced from 879 (705, 996) to 384 (319, 502) mOsm · kg-1 (P < 0.001); urine volume increased from 1.06 (0.90, 1.20) to 2.27 (1.52, 2.67) L · d-1 (P < 0.001); and baseline copeptin decreased from 12.9 (7.4, 21.9) pmol · L-1 to 7.8 (4.6;11.3) pmol · L-1 (P < 0.001). Water supplementation reduced fasting plasma glucose from a mean (SD) of 5.94 (0.44) to 5.74 (0.51) (P = 0.04). The water-associated reduction of both fasting copeptin and glucose concentration in plasma was most pronounced in participants in the top tertile of baseline copeptin.
conclusionsWater supplementation in persons with habitually low water consumption and high copeptin levels is effective in lowering copeptin. It appears a safe and promising intervention with the potential of lowering fasting plasma glucose and thus reducing diabetes risk. Further investigations are warranted to support these findings.
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