Evidence map›Paper›PMID 30566610›Full record

ArticleEndocrinology2019

Prenatal Bisphenol A Exposure in Mice Induces Multitissue Multiomics Disruptions Linking to Cardiometabolic Disorders.

Le Shu, Qingying Meng, Graciel Diamante, Brandon Tsai, Yen-Wei Chen, Andrew Mikhail, Helen Luk, Beate Ritz, Patrick Allard, Xia Yang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Maternal Nutrition, Toxicants, and Epigenetic Programming of Obesity Across Generations.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Examining the Developmental Trajectory of anEnvironmental health perspectives · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Le ShuDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California.
Qingying MengDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California.
Graciel DiamanteDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California.
Brandon TsaiDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California.
Yen-Wei ChenMolecular Toxicology Interdepartmental Program, University of California, Los Angeles, Los Angeles, California.
Andrew MikhailDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California.
Helen LukDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California.
Patrick AllardMolecular Toxicology Interdepartmental Program, University of California, Los Angeles, Los Angeles, California.
Xia YangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California.
University of California, Los Angeles · USQB3 · US

Funding

Training in Molecular ToxicologyT32ES015457 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALLARD, PATRICK, HANKINSON, OLIVER NMN · 2008 to 2025
$4.0M
DHA Reverses Gene Network Signatures of Fructose-induced Metabolic SyndromeR01DK104363 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIA · 2015 to 2019
$2.4M
Mechanisms of memory of environmental exposure: determining the role of histone modifications in regulating transgenerational behavior effects caused by environmental chemical exposure.R01ES027487 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALLARD, PATRICK · 2017 to 2021
$1.8M
NIDDK NIH HHS R01 DK104363NIEHS NIH HHS R01 ES027487NIEHS NIH HHS T32 ES015457
6 · The paper itself

Abstract

The health impacts of endocrine-disrupting chemicals (EDCs) remain debated, and their tissue and molecular targets are poorly understood. In this study, we leveraged systems biology approaches to assess the target tissues, molecular pathways, and gene regulatory networks associated with prenatal exposure to the model EDC bisphenol A (BPA). Prenatal BPA exposure at 5 mg/kg/d, a dose below most reported no-observed-adverse-effect levels, led to tens to thousands of transcriptomic and methylomic alterations in the adipose, hypothalamus, and liver tissues in male offspring in mice, with cross-tissue perturbations in lipid metabolism as well as tissue-specific alterations in histone subunits, glucose metabolism, and extracellular matrix. Network modeling prioritized main molecular targets of BPA, including Pparg, Hnf4a, Esr1, Srebf1, and Fasn as well as numerous less studied targets such as Cyp51 and long noncoding RNAs across tissues, Fa2h in hypothalamus, and Nfya in adipose tissue. Lastly, integrative analyses identified the association of BPA molecular signatures with cardiometabolic phenotypes in mouse and human. Our multitissue, multiomics investigation provides strong evidence that BPA perturbs diverse molecular networks in central and peripheral tissues and offers insights into the molecular targets that link BPA to human cardiometabolic disorders.

Indexed as

Prenatal Exposure Delayed EffectsAdipose TissueAnimalsBenzhydryl CompoundsBisphenol A CompoundsCardiovascular DiseasesEndocrine DisruptorsEpigenesis, GeneticFemaleHypothalamusLiverMaleMetabolic SyndromeMice, Inbred C57BLPhenolsPregnancyBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsPhenolsTranscription Factors

Identifiers

PMID30566610
PMCPMC6349005
OpenAlexW2949831522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.