ArticlePloS one2018
Metabolic bone disease risk factors strongly contributing to long bone and rib fractures during early infancy: A population register study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Pooled it
- Infant, maternal and pregnancy associated risk factors for offspring fractures during infancy - A population-based study.Child abuse & neglect · 2026Article
- Fractures Associated with Metabolic Bone Disease in Extremely Preterm and Extremely Low Birth Weight Infants Before and After a Bone Health Program.Children (Basel, Switzerland) · 2025Article
- Editorial on Asymptomatic Rib Fractures and Their Relationship to Child Abuse.Children (Basel, Switzerland) · 2024Article
- Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone Disease at 2 Years of Age.Children (Basel, Switzerland) · 2024Article
- Asymptomatic Infant Rib Fractures Are Primarily Non-abuse-Related and Should Not Be Used to Assess Physical Child Abuse.Children (Basel, Switzerland) · 2023Article
- Child Abuse, Misdiagnosed by an Expertise Center-Part II-Misuse of Bayes' Theorem.Children (Basel, Switzerland) · 2023Article
- Tripeptide IRW Protects MC3T3-E1 Cells against Ang II Stress in an AT2R Dependent Manner.Molecules (Basel, Switzerland) · 2022Article
- Computed Tomography Osteodensitometry for Assessment of Bone Mineral Density of the Canine Head-Preliminary Results.Animals : an open access journal from MDPI · 2021Article
- Is correcting exposure misclassification bias an additional option in meta-analyses?Clinical and experimental pediatrics · 2021Article
- The epidemiology of infant shaft fractures of femur or humerus by incidence, birth, accidents, and other causes.BMC musculoskeletal disorders · 2020Article
- Preterm birth and the future risk of orthopedic fracture.Pediatric research · 2020Article
- Maternal smoking during pregnancy and fractures in offspring: national register based sibling comparison study.BMJ (Clinical research ed.) · 2020Article
- Medical findings and symptoms in infants exposed to witnessed or admitted abusive shaking: A nationwide registry study.PloS one · 2020Article
- Parents' experiences of seeking health care and encountering allegations of shaken baby syndrome: A qualitative study.PloS one · 2020Article
- Article
- Medical diagnoses among infants at entry in out-of-home care: A Swedish population-register study.Health science reports · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to assess the incidence of fractures in infancy, overall and by type of fracture, its association with accidents, metabolic bone disease risk factors, and abuse diagnosis.
methodsThe design was a population-based register study in Sweden. Participants: Children born 1997-2014, 0-1 years of age diagnosed with fracture-diagnosis according to International Classification of Diseases (ICD10) were retrieved from the National Patient Register and linked to the Swedish Medical Birth Register and the Death Cause Register. Main outcome measures were fractures of the skull, long bone, clavicle and ribs, categorized by age (younger or older than 6 months), and accident or not.
findingsThe incidence of fractures during infancy was 251 per 100 000 infants (n = 4663). Major fracture localisations were long bone (44·9%), skull (31·7%), and clavicle (18·6%), while rib fractures were few (1·4%). Fall accidents were reported among 71·4%. One-third occurred during the first 6 months. Metabolic bone disease risk factors, such as maternal obesity, preterm birth, vitamin D deficiency, rickets, and calcium metabolic disturbances, had increased odds of fractures of long bones and ribs in early infancy (0-6 months): birth 32-36 weeks and long bone fracture [AOR 2·13 (95%CI 1·67-2·93)] and rib fracture [AOR 4·24 (95%CI 1·40-12·8)]. Diagnosis of vitamin D deficiency/rickets/disorders of calcium metabolism had increased odds of long bone fracture [AOR 49·5 (95%CI 18·3-134)] and rib fracture [AOR 617 (95%CI 162-2506)]. Fractures without a reported accident had higher odds of metabolic risk factors than those with reported accidents. Abuse diagnosis was registered in 105 infants, with overrepresentation of preterm births, multiple births and small-for-gestational age.
interpretationMetabolic bone disease risk factors are strongly associated with fractures of long bone and ribs in early infancy. Fracture cases with abuse diagnosis had a metabolic bone risk factor profile.
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