ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019
Calorie restriction reprograms diurnal rhythms in protein translation to regulate metabolism.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
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- Clock at the Core of Cancer Development.Biology · 2021Review
- Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm.Nutrients · 2020Review
- CR reprograms acetyl-CoA metabolism and induces long-chain acyl-CoA dehydrogenase and CrAT expression.Aging cell · 2020Article
- The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration.Neurobiology of disease · 2020Review
- Reduced caloric intake and periodic fasting independently contribute to metabolic effects of caloric restriction.Aging cell · 2020Article
- Endogenous circadian time genes expressions in the liver of mice under constant darkness.BMC genomics · 2020Article
- Hepatic lipid metabolism is affected by a daily 3-meal pattern with varying dietary crude protein with a pig model.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Calorie restriction (CR) delays aging and affects the circadian clocks by reprogramming circadian rhythms in gene expression. To expand on the circadian mechanisms in CR, we assayed rhythms in the protein translation by analyzing polysome-associated mRNAs in the liver of mice fed ad libitum (AL) and CR diets. Global comparison of the diets revealed that <1% of transcripts were differentially abundant in the polysomes. In contrast, the large differential, up to 10%, was detected when CR and AL diets were compared at individual times throughout the day. Most transcripts that were rhythmic under AL lost their rhythms, and many new transcripts gained rhythms under CR. Only a small fraction of transcripts, including the circadian clock genes, were rhythmic under both diets. Thus, CR strongly reprograms translation. CR affected translation of enzymes regulating long-chain acetyl-coenzyme A (Acyl-CoA) metabolism. The expression of the Acyl-CoA thioesterase (ACOT) family was induced upon CR, leading to the increased transcriptional activity of peroxisome proliferator-activated receptor α, the transcriptional factor regulated by the ACOT products. We propose that the differential translation induced by CR leads to a temporal partition and reprogramming of metabolic processes and provides a link between CR, lipid metabolism, and the circadian clock.-Makwana, K., Gosai, N., Poe, A., Kondratov, R. V. Calorie restriction reprograms diurnal rhythms in protein translation to regulate metabolism.
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