ArticleJournal of the American Chemical Society2019
Palladium-Catalyzed Dearomative syn-1,4-Diamination.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Photoinduced Hydrogenative Dearomatization With Homocoupling of Quinolines to Construct Octahydro-4,4'-biquinolines.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- Site-Selective Benzylic Dehydrogenation of Alkylindoles.JACS Au · 2025Article
- Enantioselective aza-electrophilic dearomatization of naphthalene derivatives.Nature communications · 2025Article
- Reimagining Dearomatization: Arenophile-Mediated Single-Atom Insertions and π-Extensions.Accounts of chemical research · 2025Article
- Palladium-catalyzed dearomative 1,4-hydroamination.Tetrahedron · 2024Article
- Copper-Catalyzed Dearomative 1,2-Hydroamination.Angewandte Chemie (International ed. in English) · 2024Article
- Copper-Catalyzed DearomativeACS catalysis · 2024Article
- Selective 1,4-syn-Addition to Cyclic 1,3-Dienes via Hybrid Palladium Catalysis.ACS central science · 2024Article
- Radical-Dearomative Generation of Cyclohexadienyl Pd(II) toward the 3D Transformation of Nonactivated Phenyl Rings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Recent Strategies in the Nucleophilic Dearomatization of Pyridines, Quinolines, and Isoquinolines.Chemical reviews · 2024Review
- Rejuvenation of dearomative cycloaddition reactionsChemical science · 2023Review
- Asymmetric dearomative cyclopropanation of naphthalenes to construct polycyclic compounds.Chemical science · 2022Article
- Selective skeletal editing of polycyclic arenes using organophotoredox dearomative functionalization.Nature communications · 2022Article
- Pd-catalyzed allylative dearomatisation using Grignard reagents.Chemical communications (Cambridge, England) · 2021Article
- Recent Visible Light and Metal Free Strategies in [2+2] and [4+2] Photocycloadditions.European journal of organic chemistry · 2021Review
- Recent Advances in Enantioselective Pd-Catalyzed Allylic Substitution: From Design to Applications.Chemical reviews · 2021Article
- Lewis Acid Promoted Dearomatization of Naphthols.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Catalytic three-component C-C bond forming dearomatization of bromoarenes with malonates and diazo compounds.Chemical science · 2020Article
- Palladium-catalyzed dearomative 1,4-difunctionalization of naphthalenes.Chemical science · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Herein we report a dearomative syn-1,4-diamination protocol using simple nonactivated arenes and amines. This one-pot method utilizes arene-arenophile para-cycloadducts, formed via visible-light-mediated [4+2]-photocycloaddition that undergoes formal allylic substitution with amine nucleophiles under Pd-catalysis. The products are obtained with exclusive syn-1,4-selectivity; the method permits enantioselective desymmetrization of naphthalene, as well as elaborations of amine-containing drug molecules. Furthermore, the resulting unsaturated products are amenable to numerous options for diversification. Overall, this novel dearomative functionalization strategy offers rapid and straightforward access to complex building blocks, which are difficult to prepare otherwise, from simple arenes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.