Evidence map›Paper›PMID 30566076›Full record

ArticleeLife2018

Evoked transients of pH-sensitive fluorescent false neurotransmitter reveal dopamine hot spots in the globus pallidus.

Jozsef Meszaros, Timothy Cheung, Maya M Erler, Un Jung Kang, Dalibor Sames, Christoph Kellendonk, David Sulzer

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jozsef MeszarosLaboratory for Functional Optical Imaging, Department of Biomedical Engineering, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States.ORCID http://orcid.org/0000-0002-2485-0144
Timothy CheungDepartment of Neurology, Columbia University, New York, United States.ORCID http://orcid.org/0000-0002-7516-8321
Maya M ErlerGraduate Program in Pharmacology, College of Physicians and Surgeons, Columbia University, New York, United States.
Un Jung KangDepartment of Neurology, Columbia University, New York, United States.ORCID http://orcid.org/0000-0002-5970-6839
Dalibor SamesDepartment of Chemistry and NeuroTechnology Center, Columbia University, New York, United States.
Christoph KellendonkDivision of Molecular Therapeutics, New York State Psychiatric Institute, New York, United States.ORCID http://orcid.org/0000-0003-3302-2188
David SulzerDepartment of Neurology, Columbia University, New York, United States.ORCID http://orcid.org/0000-0001-7632-0439
Columbia University · USNew York Psychoanalytic Society and Institute · USOptica · US

Funding

The Dopamine Synapse and Associative LearningR01DA007418 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David Sulzer · 1999 to 2026
$9.4M
Development of Fluorescent False NeurotransmittersR01MH108186 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SAMES, DALIBOR, SULZER, DAVID · 2015 to 2024
$5.8M
Medium Spiny Neuron Excitability and MotivationR01MH093672 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KELLENDONK, CHRISTOPH · 2011 to 2020
$5.0M
Pathological striatopallidal neuronalensembles in learned motor impairment in PDR01NS107734 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KANG, UN JUNG · 2018 to 2022
$1.8M
The striatal cholinergic interneurons in Parkinson's disease and treatmentR01NS101982 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KANG, UN JUNG · 2017 to 2020
$1.8M
The role of striatal cholinergic interneurons in Parkinson’s diseaseR56NS095053 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KANG, UN JUNG · 2016 to 2016
$488k
Plasticity of bridge collaterals in Parkinonian state and treatmentR03NS096494 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KANG, UN JUNG · 2016 to 2017
$160k
NIDA NIH HHS R01 DA007418NIDA NIH HHS R01 DA07418NIH HHS R01 DA07418NIH HHS R01 NS101982NIH HHS R03 NS096494NIH HHS RO1 MH093672NIH HHS T32 NS06492B-04NIMH NIH HHS R01 MH093672NIMH NIH HHS R01 MH108186NIMH NIH HHS RO1 MH093672NINDS NIH HHS R01 NS101982NINDS NIH HHS R01 NS107734NINDS NIH HHS R03 NS096494NINDS NIH HHS R56 NS095053
6 · The paper itself

Abstract

Dopamine neurotransmission is suspected to play important physiological roles in multiple sparsely innervated brain nuclei, but there has not been a means to measure synaptic dopamine release in such regions. The globus pallidus externa (GPe) is a major locus in the basal ganglia that displays a sparse innervation of

Indexed as

AnimalsAxonsBasal GangliaDopamineFemaleGlobus PallidusHydrogen-Ion ConcentrationMaleMice, Inbred C57BLMice, KnockoutMice, TransgenicNeurotransmitter AgentsSubstantia NigraSynaptic TransmissionDopamineNeurotransmitter Agentsbasal gangliadopamineexocytosisexternal globus pallidusFFNmouseneuroscience

Identifiers

PMID30566076
PMCPMC6324876
OpenAlexW2904695839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.