ArticleCirculation research2018
Serum Beta Carotene and Overall and Cause-Specific Mortality.
Article in Circulation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Pooled it
- Dietary Selenium and β-Carotene Contribute to the Inverse Association Between Antioxidant Mixtures and Stroke: Evidence From NHANES Using Mixture Models and Machine Learning.Food science & nutrition · 2026Article
- Biological Aging Mediates the Associations Between Multiple Serum Micronutrients and All-Cause Mortality Among U.S. Adults.Biological trace element research · 2026Article
- Lower Micronutrient Intake in Patients with Coronary Artery Disease: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Genetic Determinants of Interindividual Differences in Provitamin A Carotenoid Concentrations in Human Adipose Tissue.Molecular nutrition & food research · 2026Observational
- Association between serum carotenoid concentrations and risk of all-cause and cause-specific mortality in individuals with osteoarthritis.Clinical rheumatology · 2026Article
- Comparison of Nutrient Intake Across Different Dietary Patterns in Brazilian Community-Dwelling Older Adults.Nutrients · 2025Article
- Dietary carotenoid intakes and biological aging among US adults, NHANES 1999-2018.Nutrition journal · 2025Article
- Dietary antioxidant nutrients intake and pneumonia mortality in Japanese men and women: the Japan Public Health Center-Based Prospective Study.Environmental health and preventive medicine · 2025Article
- Immunometabolic effects ofImmunometabolism (Cobham, Surrey) · 2024Review
- Post-diagnostic multivitamin supplement use and colorectal cancer survival: A prospective cohort study.Cancer · 2024Article
- Association between atherosclerotic cardiovascular disease score and skin carotenoid levels estimated via refraction spectroscopy in the Japanese population: a cross-sectional study.Scientific reports · 2024Article
- Ratio of Red Blood Cell Distribution Width to Albumin Level and Risk of Mortality.JAMA network open · 2024Article
- Article
- β-carotene accelerates the resolution of atherosclerosis in mice.bioRxiv : the preprint server for biology · 2024Article
- β‑carotene attenuates muscle wasting in cancer cachexia by regulating myogenesis and muscle atrophy.Oncology reports · 2024Article
- Association between dietaryFrontiers in nutrition · 2024Article
- Associations of multiple carotenoid co-exposure with all-cause and cause-specific mortality in US adults: a prospective cohort study.Frontiers in nutrition · 2024Article
- Pharmacological effects and target analysis of Guipi wan in the treatment of cerebral ischemia-reperfusion injury.Frontiers in pharmacology · 2024Article
- The Colombo Twin and Singleton Study (COTASS): Piloting the Feasibility of Collecting Nutritional Data and Extension of the Sample to Include Children of Twins.Behavior genetics · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleAlthough the health effects of beta carotene have been studied extensively, a systematic examination of serum concentrations and long-term mortality, including cardiovascular disease mortality, has not been reported.
objectiveExplore whether serum beta carotene is associated with overall and cause-specific mortality and to elucidate the strength and dose-response of the association. METHODS AND
resultsWe conducted a prospective serological analysis of 29 103 men in the ATBC study (Alpha-Tocopherol, Beta-Carotene Cancer Prevention). During 31 years of follow-up, 23 796 deaths occurred, including deaths because of cardiovascular disease (9869), cancer (7692), respiratory disease (2161), diabetes mellitus (119), injuries and accidents (1255), and other causes (2700). Serum beta carotene was assayed using high-performance liquid chromatography. Adjusting for major risk factors measured, men with higher serum beta carotene had significantly lower all-cause mortality (hazard ratios=0.81, 0.71, 0.69, and 0.64 for quintile 2 (Q2)-Q5 versus Q1, respectively; P
conclusionsThis study provides evidence that higher beta carotene biochemical status is associated with lower overall, cardiovascular disease, heart disease, stroke, cancer, and other causes of mortality. The dose-response associations over a 30-year period were not attenuated by adjustment for other important risk factors and support greater fruit and vegetable consumption as a means to increase beta carotene status and promote longevity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.