Evidence map›Paper›PMID 30566022›Full record

ArticleCirculation2018

Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart.

Lauren E Neidig, Florian Weinberger, Nathan J Palpant, John Mignone, Amy M Martinson, Daniel W Sorensen, Ingrid Bender, Natsumi Nemoto, Hans Reinecke, Lil Pabon and 3 more

Abstract readLetter
In one paragraph

Article in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Pluripotent stem cell-based approaches for heart repair and the potential of genetic modifications.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  2. Article
  3. Review
  4. Unravelling the Interplay between Cardiac Metabolism and Heart Regeneration.International journal of molecular sciences · 2023
    Review
  5. Review
  6. Article
  7. Review
  8. Cardiac regeneration: Options for repairing the injured heart.Frontiers in cardiovascular medicine · 2022
    Review
  9. Review
  10. Article
  11. Review
  12. Cardiac Cell Therapy: Insights into the Mechanisms of Tissue Repair.International journal of molecular sciences · 2021
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Lauren E NeidigDepartment of Pathology (L.E.N., F.W., N.J.P., A.M.M., H.R., L.P., C.E.M.), University of Washington, Seattle.
Florian WeinbergerDepartment of Pathology (L.E.N., F.W., N.J.P., A.M.M., H.R., L.P., C.E.M.), University of Washington, Seattle.
Nathan J PalpantDepartment of Pathology (L.E.N., F.W., N.J.P., A.M.M., H.R., L.P., C.E.M.), University of Washington, Seattle.
John MignoneInstitute for Stem Cell and Regenerative Medicine (L.E.N., F.W., N.J.P., J.M., A.M.M., H.R., L.P., C.E.M.), University of Washington, Seattle.
Amy M MartinsonDepartment of Pathology (L.E.N., F.W., N.J.P., A.M.M., H.R., L.P., C.E.M.), University of Washington, Seattle.
Daniel W SorensenStem Cell Institute and Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis (D.W.S., I.B., N.N., J.H.v.B.).
Ingrid BenderStem Cell Institute and Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis (D.W.S., I.B., N.N., J.H.v.B.).
Natsumi NemotoStem Cell Institute and Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis (D.W.S., I.B., N.N., J.H.v.B.).
Hans ReineckeDepartment of Pathology (L.E.N., F.W., N.J.P., A.M.M., H.R., L.P., C.E.M.), University of Washington, Seattle.
Lil PabonDepartment of Pathology (L.E.N., F.W., N.J.P., A.M.M., H.R., L.P., C.E.M.), University of Washington, Seattle.
Jeffery D MolkentinDepartment of Pediatrics, Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (J.D.M.).
Charles E MurryDepartment of Pathology (L.E.N., F.W., N.J.P., A.M.M., H.R., L.P., C.E.M.), University of Washington, Seattle.
Jop H van BerloStem Cell Institute and Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis (D.W.S., I.B., N.N., J.H.v.B.).

Funding

Vascularization and Growth of Human Myocardial GraftsP01HL094374 · NHLBI · UNIVERSITY OF WASHINGTON · PI MURRY, CHARLES E · 2010 to 2014
$14.5M
Primate Heart RegenerationR01HL128362 · NHLBI · UNIVERSITY OF WASHINGTON · PI MURRY, CHARLES E · 2016 to 2019
$3.5M
Strategic activation of endogenous c-kit+ progenitor cells for cardiac regenerationR01HL130072 · NHLBI · UNIVERSITY OF MINNESOTA · PI VAN BERLO, JOHANNES (JOP) · 2016 to 2020
$1.9M
Functional relevance of cardiac regeneration by c-kit positive stem cellsR00HL112852 · NHLBI · UNIVERSITY OF MINNESOTA · PI VAN BERLO, JOHANNES (JOP) · 2013 to 2015
$712k
Stem Cell Biology Training ProgramT32GM113846 · NIGMS · UNIVERSITY OF MINNESOTA · PI PERLINGEIRO, RITA C. R. · 2015 to 2019
$712k
NHLBI NIH HHS P01 HL094374NHLBI NIH HHS R00 HL112852NHLBI NIH HHS R01 HL128362NHLBI NIH HHS R01 HL130072NIGMS NIH HHS T32 GM113846
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adult Stem CellsAnimalsAntigens, LyCell DifferentiationCell LineageCells, CulturedCell Self RenewalEndothelial CellsHumansMembrane ProteinsMiceMice, TransgenicModels, AnimalMuscle DevelopmentMyocardial InfarctionMyocytes, CardiacAntigens, LyLy6a protein, mouseMembrane ProteinsTamoxifenheart failuremyocardial infarctionprogenitor cellsregeneration

Identifiers

PMID30566022
PMCPMC6296850

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.