← GLP-1 receptor agonists × cardiovascular events

TrialCirculation2018

Effects of Liraglutide on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus With or Without History of Myocardial Infarction or Stroke.

Subodh Verma et al.PubMed ↗Publisher ↗

A later paper about NCT01179048. The trial’s primary report, PMID 27295427, speaks for it on the map; the numbers here are shown and do not vote.

What the trial testedrandomised · 9,340 people · 2018

Randomised comparison

Reduced cardiovascular events

Doesn’t vote: a later paper about the trial

−15%−27% to −1%

17 in 100 instead of 20

Bigger than 3 in 10 for cardiovascular events

As reported

HR 0.85, 95% CI 0.73–0.99

Randomised comparison

Reduced cardiovascular events

Doesn’t vote: a later paper about the trial

−24%−38% to −6%

10 in 100 instead of 13

Bigger than 6 in 10 for cardiovascular events

As reported

HR 0.76, 95% CI 0.62–0.94

Two numbers in the abstract

the abstract, start to end

… of 1827 patients [20.4%]; hazard ratio, 0.85; 95% CI, 0.73-0.99) and in those with established atherosclerotic cardiovascular disease without MI/stroke (158 of 1538 [10.3%] versus 199 of 1545 patients [12.9%]; hazard ratio, 0.76; 95% CI, 0.62-0.94) compared …

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
HR 0.850.73–0.99
Cardiovascular events
HR 0.760.62–0.94
GLP-1 receptor agonistsCardiovascular events
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60 papers cite it

2018
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this paperpooled ittrialcites it

The trial

NCT01179048phase 39,341 enrolled2010a later paper about it
Full record →Abstract, authors, funding and every citing paper · PMID 30566004