ArticleJournal of psychiatry & neuroscience : JPN2019
Lifetime major depression and grey-matter volume
Article in Journal of psychiatry & neuroscience : JPN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder.Translational psychiatry · 2022Pooled it
- Depressive symptoms and neuroimaging markers of brain aging in an ethno-racially diverse sample: a Bayesian analysis.American journal of epidemiology · 2026Article
- Examination of poverty trajectories and brain volume as predictors of adolescent depression.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- The cross-site reproducibility of MRI morphometric phenotypes in psychiatric disorders.Nature neuroscience · 2026Article
- Moderate Food Preferences and Depression with Grey Matter as a Potential Mediator: A Large-Scale Longitudinal Study.Foods (Basel, Switzerland) · 2026Article
- The Relationship Between Polygenic Risk of Depression and Regional Brain Atrophy in Older Adults.International journal of geriatric psychiatry · 2026Article
- Incomplete network restoration may be associated with higher relapse risk in women with major depressive disorder.Psychiatry and clinical neurosciences · 2026Article
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Chronicity moderates the impact of severity on central executive-default mode network functional interactions in depression.Scientific reports · 2026Article
- Causal relationship between obesity, leptin, and brain structure and functional connectivity: evidence based on bidirectional and mediation mendelian randomisation analyses.Nutrition & metabolism · 2026Article
- Hypothalamus volumes and mental health in children and adolescents.Frontiers in neuroscience · 2026Article
- Complex Neurobiological Mechanisms and Risk Factors Underlying Late-Life Depression.Advances in experimental medicine and biology · 2026Review
- Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cortical functional and structural alterations in rhegmatogenous retinal detachment: a multimodal analysis using surface-based independent component analysis, morphometry, and machine learning.Quantitative imaging in medicine and surgery · 2025Article
- Limbic gray matter increases in response to cognitive-behavioral therapy in major depressive disorder.Translational psychiatry · 2025Article
- Hippocampal, thalamic, and amygdala subfield morphology in major depressive disorder: an ultra-high resolution MRI study at 7-Tesla.European archives of psychiatry and clinical neuroscience · 2025Article
- Integrating brain imaging features and genomic profiles for the subtyping of major depression.Psychological medicine · 2025Article
- Effects of depression and anxiety symptoms on cognitive inhibition: A cross-sectional study of structural and functional MRI evidence.Medicine · 2025Observational
- Over-integration of visual network in major depressive disorder and its association with gene expression profiles.Translational psychiatry · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There is evidence of structural brain alterations in major depressive disorder (MDD), but little is known about how these alterations might be affected by age at onset or genetic vulnerability. This study examines whether lifetime episodes of MDD are associated with specific alterations in grey-matter volume, and whether those alterations vary according to sex or serotonin transporter-linked promoter region (5-HTTLPR) genotype (LL, SL or SS). Methods: We used structural MRI to acquire anatomic scans from 610 community-dwelling participants. We derived quantitative regional estimates of grey-matter volume in 16 subregions using FreeSurfer software. We diagnosed MDD according to DSM-IV criteria. We adjusted analyses for age, sex, total brain volume, education level, head injury and comorbidities. Results: Lifetime MDD was associated with a smaller insula, thalamus, ventral diencephalon, pallidum and nucleus accumbens and with a larger pericalcarine region in both men and women. These associations remained after adjustment for false discovery rate. Lifetime MDD was also associated with a smaller caudate nucleus and amygdala in men and with a larger rostral anterior cingulate cortex in women. Late-onset first episodes of MDD (after age 50 years) were associated with a larger rostral anterior cingulate cortex and lingual and pericalcarine regions; early-onset MDD was associated with a smaller ventral diencephalon and nucleus accumbens. Some associations differed according to 5-HTTLPR genotype: the thalamus was smaller in participants with MDD and the LL genotype; pericalcarine and lingual volumes were higher in those with the SL genotype. Limitations: This study was limited by its cross-sectional design. Conclusion: Major depressive disorder was associated with persistent volume reductions in the deep nuclei and insula and with enlargements in visual cortex subregions; alterations varied according to age of onset and genotype.
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