Evidence map›Paper›PMID 30565852›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019

Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8

Douglas R Mathern, Julian K Horwitz, Peter S Heeger

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Emerging roles for complement in lung transplantation.The Journal of clinical investigation · 2025
    Review
  2. Dual role of complement in neuronal repair.Frontiers in immunology · 2025
    Review
  3. The Transplant Bellwether: Endothelial Cells in Antibody-Mediated Rejection.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  4. Review
  5. Absence of TSC1 Accelerates CD8Aging and disease · 2022
    Article
  6. Review
  7. Article
  8. The Footprint of Kynurenine Pathway in Cardiovascular Diseases.International journal of tryptophan research : IJTR · 2022
    Review
  9. Review
  10. Sterile inflammation in thoracic transplantation.Cellular and molecular life sciences : CMLS · 2021
    Review
  11. Article
  12. Article
  13. Targeting of G-protein coupled receptors in sepsis.Pharmacology & therapeutics · 2020
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Douglas R MathernTranslational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York.
Julian K HorwitzTranslational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York.
Peter S HeegerTranslational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0003-4673-6913

Funding

Complement & T Cell Medicated Allograft RejectionR01AI071185 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT · 2007 to 2016
$4.3M
Immunology Training GrantT32AI007605 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI LIRA, SERGIO A. · 2001 to 2017
$2.2M
NIAID NIH HHS R01 AI071185NIAID NIH HHS T32 AI007605
6 · The paper itself

Abstract

Activation, differentiation, and expansion of alloreactive CD8

Indexed as

Heart TransplantationAdoptive TransferAllograftsAnimalsCD8-Positive T-LymphocytesCell DifferentiationCytokinesFemaleGraft SurvivalHumansImmunosuppressive AgentsIsoantigensLymphocyte ActivationMaleMiceMice, Inbred BALB Ccomplement C3a receptorCytokinesImmunosuppressive AgentsIsoantigensReceptors, ComplementTacrolimusanimal models: murinebasic (laboratory) research/sciencecomplement biologyimmunobiologyimmunosuppressant - calcineurin inhibitor (CNI)T cell biology

Identifiers

PMID30565852
PMCPMC6538425

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.