Evidence map›Paper›PMID 30565635›Full record

ArticleSoft matter2019

Colloid supported lipid bilayers for self-assembly.

Melissa Rinaldin, Ruben W Verweij, Indrani Chakraborty, Daniela J Kraft

Abstract read
In one paragraph

Article in Soft matter, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Life-like behavior emerging in active and flexible microstructures.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
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  4. Article
  5. Article
  6. Article
  7. DNA self-organization controls valence in programmable colloid design.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Direct visualization of superselective colloid-surface binding mediated by multivalent interactions.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Melissa RinaldinHuygens-Kamerlingh Onnes Lab, Universiteit Leiden, P.O. Box 9504, 2300 RA Leiden, The Netherlands. kraft@physics.leidenuniv.nl.
Ruben W Verweij
Indrani Chakraborty
Daniela J Kraft

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of colloid supported lipid bilayers (CSLBs) has recently been extended to create colloidal joints, that enable the assembly of structures with internal degrees of flexibility, and to study lipid membranes on curved and closed geometries. These novel applications of CSLBs rely on previously unappreciated properties: the simultaneous fluidity of the bilayer, lateral mobility of inserted (linker) molecules and colloidal stability. Here we characterize every step in the manufacturing of CSLBs in view of these requirements using confocal microscopy and fluorescence recovery after photobleaching (FRAP). Specifically, we have studied the influence of different particle properties (roughness, surface charge, chemical composition, polymer coating) on the quality and mobility of the supported bilayer. We find that the insertion of lipopolymers in the bilayer can affect its homogeneity and fluidity. We improve the colloidal stability by inserting lipopolymers or double-stranded inert DNA into the bilayer. We include surface-mobile DNA linkers and use FRAP to characterize their lateral mobility both in their freely diffusive and bonded state. Finally, we demonstrate the self-assembly of flexibly linked structures from the CSLBs modified with surface-mobile DNA linkers. Our work offers a collection of experimental tools for working with CSLBs in applications ranging from controlled bottom-up self-assembly to model membrane studies.

Identifiers

PMID30565635
PMCPMC6371764

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.