ArticleThe FEBS journal2019
Chorioamnionitis exposure remodels the unique histone modification landscape of neonatal monocytes and alters the expression of immune pathway genes.
Article in The FEBS journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Reconceptualizing chorioamnionitis as an immune-mediated inflammatory disorder at the maternal-fetal interface.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- The Interplay of One-Carbon Metabolism, Mitochondrial Function, and Developmental Programming in Ruminant Livestock.Journal of developmental biology · 2026Review
- Epigenetics and bronchopulmonary dysplasia: unraveling the complex interplay and potential therapeutic implications.Pediatric research · 2024Article
- Neonatal immune cells have heightened responses following in-utero exposure to chorioamnionitis or COVID-19.Pediatric research · 2024Article
- The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring.Journal of clinical medicine · 2024Article
- The Influence of Maternal High Fat Diet During Lactation on Offspring Hematopoietic Priming.Endocrinology · 2023Article
- Sex-associated early-life viral innate immune response is transcriptionally associated with chromatin remodeling of type-I IFN-inducible genes.Mucosal immunology · 2023Article
- Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis, and Clinically Diagnosed Postnatal Infection.Pediatric reports · 2023Article
- Chorioamnionitis-exposure alters serum cytokine trends in premature neonates.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Omics approaches: interactions at the maternal-fetal interface and origins of child health and disease.Pediatric research · 2023Review
- Differences in H3K4me3 and chromatin accessibility contribute to altered T-cell receptor signaling in neonatal naïve CD4 T cells.Immunology and cell biology · 2022Article
- Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth.JCI insight · 2022Article
- Epigenetic regulation of pediatric and neonatal immune responses.Pediatric research · 2022Review
- Genome-wide postnatal changes in immunity following fetal inflammatory response.The FEBS journal · 2021Article
- Role of Maternal Infections and Inflammatory Responses on Craniofacial Development.Frontiers in oral health · 2021Review
- Preterm Birth Is Associated With Immune Dysregulation Which Persists in Infants Exposed to Histologic Chorioamnionitis.Frontiers in immunology · 2021Article
- Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms.Frontiers in immunology · 2020Review
- Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease.Frontiers in immunology · 2020Review
- Intrauterine programming of obesity and type 2 diabetes.Diabetologia · 2019Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Chorioamnionitis is an intrauterine infection involving inflammation of the chorion, amnion, and placenta. It leads to a fetal systemic inflammatory response that can alter the transcription of neonatal immune genes. We have previously shown that neonatal monocytes gain the activating histone tail modification H3K4me3 at promoter sites of immunologically important genes as development progresses from preterm neonate to adult. In this study, we applied ChIP-seq and RNA-seq to evaluate the impact of chorioamnionitis on the neonatal monocyte H3K4me3 histone modification landscape over the course of fetal and neonatal immune system development. Chorioamnionitis exposure in neonatal monocytes resulted in a net increase in total monocyte H3K4me3, primarily in introns and intergenic regions. Immune gene expression was decreased in chorioamnionitis-exposed monocytes, with the majority of enriched transcripts falling into pathways that are not linked to the immune system. Over half of all neonatal monocyte H3K4me3 peaks, independent of their location, were associated with active gene transcription. Overall, chorioamnionitis exposure resulted in the global remodeling of the neonatal monocyte H3K4me3 landscape and changes in the expression of known immune genes. These changes resulted in a less robust inflammatory response upon exposure to a secondary challenge, which may explain why chorioamnionitis-exposed neonates have an increased risk of sepsis. DATABASE: ChIP-seq data for U30/O30/Term: GEO GSE81957 ChIP-seq data for U30C/O30C/TermC: GEO GSE111873 RNA-seq data for U/L/CU/CL: GEO GSE111927.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.