SynthesisTropical medicine & international health : TM & IH2019
The willingness to participate in biomedical research involving human beings in low- and middle-income countries: a systematic review.
Synthesis in Tropical medicine & international health : TM & IH, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Factors related to willingness to participate in biomedical research on neglected tropical diseases: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Parental motivations, facilitators, and barriers to participating in a pediatric vaccine trial in Kathmandu, Nepal: A qualitative study.Human vaccines & immunotherapeutics · 2026Article
- Article
- Article
- Balancing altruism, risk and ethics: Vietnamese students' views on human challenge studies.PloS one · 2026Article
- Bridging Trust and Collaborative Research in Low-Income Contexts During Public Health Emergencies: A Sierra Leone Case Study.Health science reports · 2025Article
- Through the eyes of the participant: using photovoice to understand the experiences and effects of ivermectin MDA in the context of the BOHEMIA clinical trial in Kwale, Kenya.Malaria journal · 2025Article
- Using the health belief model to examine adolescent participation in HIV prevention research in Kampala, Uganda: A qualitative study.PLOS global public health · 2025Article
- Scoping review and thematic analysis of informed consent in humanitarian emergencies.BMC medical ethics · 2024Article
- Interest in I-PrEP and Willingness to Participate in Clinical Trials Among Men and Transfeminine Persons Who have Sex with Men in Sub-Saharan Africa: Quantitative and Qualitative Findings from HPTN 075.AIDS and behavior · 2024Article
- Influences on clinical trial participation: Enhancing recruitment through a gender lens - A scoping review.Contemporary clinical trials communications · 2024Article
- Public perceptions and expectations: Disentangling the hope and hype of organoid research.Stem cell reports · 2023Article
- Fibromyalgia Rapid Screening Tool (FiRST): Arabic Translation and Cross-Cultural Adaptation and Validation.Healthcare (Basel, Switzerland) · 2023Article
- Willingness to Use Male Contraceptive Pill: Spain-Mozambique Comparison.International journal of environmental research and public health · 2023Article
- Fragmented understanding: exploring the practice and meaning of informed consent in clinical trials in Ho Chi Minh City, Vietnam.BMC medical ethics · 2023Article
- Factors affecting trust in clinical trials conduct: Views of stakeholders from a qualitative study in Ghana.PLOS global public health · 2023Article
- Social capital and willingness to participate in COVID-19 vaccine trials: an Italian case-control study.BMC public health · 2022Article
- Prevalence of abnormal liver tests and liver fibrosis among rural adults in low and middle-income country: A cross-sectional study.EClinicalMedicine · 2022Article
- The research output of rod-cone dystrophy genetics.Orphanet journal of rare diseases · 2022Review
- Why Vaccinate Against COVID-19? A Population-Based Survey in Switzerland.International journal of public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo systematically review reasons for the willingness to participate in biomedical human subjects research in low- and middle-income countries (LMICs).
methodsFive databases were systematically searched for articles published between 2000 and 2017 containing the domain of 'human subjects research' in 'LMICs' and determinant 'reasons for (non)participation'. Reasons mentioned were extracted, ranked and results narratively described.
resultsNinety-four articles were included, 44 qualitative and 50 mixed-methods studies. Altruism, personal health benefits, access to health care, monetary benefit, knowledge, social support and trust were the most important reasons for participation. Primary reasons for non-participation were safety concerns, inconvenience, stigmatisation, lack of social support, confidentiality concerns, physical pain, efficacy concerns and distrust. Stigmatisation was a major concern in relation to HIV research. Reasons were similar across different regions, gender, non-patient or patient participants and real or hypothetical study designs.
conclusionsAddressing factors that affect (non-)participation in the planning process and during the conduct of research may enhance voluntary consent to participation and reduce barriers for potential participants.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.