SynthesisNeurocritical care2019
Intracranial Hypertension After Spontaneous Intracerebral Hemorrhage: A Systematic Review and Meta-analysis of Prevalence and Mortality Rate.
Synthesis in Neurocritical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Clinical benefits of invasive intracranial pressure monitoring for spontaneous intracranial hemorrhage: a systematic review and meta-analysis.Journal of neurology · 2025Pooled it
- Perihematomal Edema and Clinical Outcome After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.Neurocritical care · 2022Pooled it
- Intracranial Pressure Estimation Using B4C Device: A Systematic Review on the Validation Studies.Neurocritical care · 2026Review
- A LGBM model for predicting alimentary tract hemorrhage after intracerebral hemorrhage surgery: association with malnutrition risk and poor neurological recovery.Frontiers in medicine · 2026Article
- The Role of ICP Monitoring in Minimally Invasive Surgery for the Management of Intracerebral Hemorrhage.Translational stroke research · 2025Review
- Clinical characteristics and prognostic analysis of patients with hydrocephalus after hypertensive cerebral haemorrhage: a retrospective case-control study.Neurosurgical review · 2025Article
- Risk factors and model construction for early neurological deterioration in patients with intracerebral hemorrhage.Frontiers in neurology · 2025Article
- Article
- Intracranial Pressure Dysfunction Following Severe Intracerebral Hemorrhage in Middle-Aged Rats.Translational stroke research · 2023Article
- Comparison of Cerebral Autoregulation Above and Below the Tentorium of the Cerebellum In Neurosurgical Patients with Transtentorial ICP Gradient.Neurocritical care · 2023Article
- Intracranial Pressure Monitoring for Acute Brain Injured Patients: When, How, What Should We Monitor.Korean journal of neurotrauma · 2023Review
- Intracerebral haemorrhage.Nature reviews. Disease primers · 2023Review
- Animal models for the study of intracranial hematomas (Review).Experimental and therapeutic medicine · 2023Review
- A review of invasive intracranial pressure monitoring following surgery for hypertensive cerebral hemorrhage.Frontiers in neurology · 2023Review
- Relationship between edema and intracranial pressure following intracerebral hemorrhage in rat.Frontiers in stroke · 2023Review
- Endoscopic surgery versus craniotomy in the treatment of spontaneous intracerebral hematoma: a systematic review and meta-analysis.Chinese neurosurgical journal · 2022Article
- Clinical Significance of Multiparameter Intracranial Pressure Monitoring in the Prognosis Prediction of Hypertensive Intracerebral Hemorrhage.Journal of clinical medicine · 2022Article
- Statins on Spontaneous Intracerebral Hemorrhage: A Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- A Prediction Model for Neurological Deterioration in Patients with Acute Spontaneous Intracerebral Hemorrhage.Frontiers in surgery · 2022Article
- Spontaneous intracerebral hemorrhage, initial computed tomography (CT) scan findings, clinical manifestations and possible risk factors.American journal of nuclear medicine and molecular imaging · 2022Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to determine the prevalence of intracranial hypertension (IHT) and the associated mortality rate in patients who suffered from primary intracerebral hemorrhage (ICH). A secondary objective was to assess predisposing factors to IHT development. We conducted a systematic literature search of major electronic databases (MEDLINE, EMBASE, and Cochrane Library), for studies that assessed intracranial pressure (ICP) monitoring in patients with acute ICH. Study level and outcome measures were extracted. The meta-analysis was performed using a random-effects model. A total of six studies comprising 381 patients were pooled to estimate the overall prevalence of any episode of IHT (ICP > 20 mmHg) after ICH. The pooled prevalence rate for any episode of IHT after ICH was 67% (95% CI 51-84%). Four studies comprising 239 patients were pooled in order to estimate the overall mortality rate associated with IHT. Pooled mortality rate was 50% (95% CI 24-76%). For both outcomes, heterogeneity was statistically significant, and risk of bias was nonsignificant. Reported variables correlated significantly with increased ICP were lower Glasgow Coma Scale score at admission, midline shift, hemorrhage volume, and hydrocephalus. The prevalence and mortality rates associated with IHT after ICH are high and may be underestimated. Predicting factors for the development of IHT reflect the magnitude of the primary injury. However, the results of present meta-analysis should be interpreted with caution due to methodological limitations such as selection bias of patients who had ICP monitoring, and lack of standardized IHT definition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.