ReviewChemistry Central journal2018
Therapeutic importance of synthetic thiophene.
Review in Chemistry Central journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 236 citations in OpenAlex.
- Design, Synthesis, and Cytotoxic Evaluation ofMolecules (Basel, Switzerland) · 2026Article
- Cationic Amphiphiles with Five-Membered Heterocyclic Linkers: Synthesis, Self-Assembly, and DNA Complexation Properties.Materials (Basel, Switzerland) · 2026Article
- Photochemical skeletal editing: one-step transformation of diaryl dithiophenes into regiodefined helicenes.Chemical science · 2026Article
- Nanoparticle-Catalysed Microwave-Driven MCRs for Sustainable Heterocycle Synthesis.Molecules (Basel, Switzerland) · 2026Review
- Development of new pyrazole-thiophene hybrids: synthesis, anticancer assessment, and molecular docking insights.RSC advances · 2026Article
- Substrate-Selective Temperature-Controlled Synthesis of Thiophene Derivatives at Interfaces.Angewandte Chemie (International ed. in English) · 2026Article
- Unveiling the Therapeutic Spectrum of Annona reticulata Linn.: Antibacterial, Insecticidal, and Antidiarrheal Insights.TheScientificWorldJournal · 2026Article
- Synthesis of unprotected thienyl sulfonamides and their activities against carbapenem-resistantRSC advances · 2025Article
- Synthesis and antimicrobial activity of thiophene-functionalized Ag(I) and Au(I) N-heterocyclic carbene complexes against ampicillin-resistant Staphylococcus aureus.Scientific reports · 2025Article
- 2-(Methoxycarbonyl)thiophen-3-yl-diazonium Salts: Efficient Precursors for the Formation of C-C Bonds in Thiophene-Containing Heterocyclic Systems.Molecules (Basel, Switzerland) · 2025Article
- Solvent-driven spectroscopic and quantum chemical evaluation of 2-[(trimethylsilyl) ethynyl]thiophene with molecular docking insights.Scientific reports · 2025Article
- Unlocking Therapeutic Potential of Novel Thieno-Oxazepine Hybrids as Multi-Target Inhibitors of AChE/BChE and Evaluation Against Alzheimer's Disease: In Vivo, In Vitro, Histopathological, and Docking Studies.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Novel Compounds Featuring a Thiophene Carboxamide Scaffold: Synthesis, Characterization and Antiproliferative Evaluation.International journal of molecular sciences · 2025Article
- Article
- Orofacial antinociceptive effect of a novel 2-amino-thiophene derivative and its possible targets of action.Brazilian oral research · 2025Article
- Assessment of In Vivo Analgesic, Anti-Inflammatory and Wound Healing Properties of Aqueous Leaf Extract ofTheScientificWorldJournal · 2025Article
- Synthesis, characterization, biological activities, and computational studies of pyrazolyl-thiazole derivatives of thiophene.RSC advances · 2024Article
- Synthesis of 2-Ethylhexyl 5-Bromothiophene-2-Carboxylates; Antibacterial Activities againstMolecules (Basel, Switzerland) · 2024Article
- Exploring the ultrafast and isomer-dependent photodissociation of iodothiophenesPhysical chemistry chemical physics : PCCP · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thiophene and its substituted derivatives are very important class of heterocyclic compounds which shows interesting applications in the field of medicinal chemistry. It has made an indispensable anchor for medicinal chemists to produce combinatorial library and carry out exhaustive efforts in the search of lead molecules. It has been reported to possess a wide range of therapeutic properties with diverse applications in medicinal chemistry and material science, attracting great interest in industry as well as academia. It has been proven to be effectual drugs in present respective disease scenario. They are remarkably effective compounds both with respect to their biological and physiological functions such as anti-inflammatory, anti-psychotic, anti-arrhythmic, anti-anxiety, anti-fungal, antioxidant, estrogen receptor modulating, anti-mitotic, anti-microbial, kinases inhibiting and anti-cancer. Thus the synthesis and characterization of novel thiophene moieties with wider therapeutic activity is a topic of interest for the medicinal chemist to synthesize and investigate new structural prototypes with more effective pharmacological activity. However, several commercially available drugs such as Tipepidine, Tiquizium Bromides, Timepidium Bromide, Dorzolamide, Tioconazole, Citizolam, Sertaconazole Nitrate and Benocyclidine also contain thiophene nucleus. Therefore, it seems to be a requirement to collect recent information in order to understand the current status of the thiophene nucleus in medicinal chemistry research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.