ArticleMetabolic brain disease2019
Acute stress response to a cognitive task in patients with major depressive disorder: potential metabolic and proinflammatory biomarkers.
Article in Metabolic brain disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Is cardiac autonomic control affected in major depressive disorder? A systematic review of heart rate variability studies.Translational psychiatry · 2025Pooled it
- Association between triglyceride and depression: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Association of peripheral manifestation of brain-derived neurotrophic factor with depression: A meta-analysis.Brain and behavior · 2022Pooled it
- Physiological responses to acute psychological stress as a biomarker for depression: A systematic review and meta-analysis.Psychological bulletinPooled it
- Effect of Combined Thoracic Paravertebral Block and General Anesthesia vs General Anesthesia Alone on Postoperative Stress and Pain in Patients Undergoing Laparoscopic Radical Nephrectomy.Medical science monitor : international medical journal of experimental and clinical research · 2022Trial
- Elevated Serum Cortisol Levels in Patients with Focal Epilepsy, Depression, and Comorbid Epilepsy and Depression.International journal of molecular sciences · 2022Article
- Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective.Frontiers in psychiatry · 2022Review
- Better forbearance, lower depression: Evidence based on heart rate variability.Frontiers in psychology · 2022Article
- Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature.Brain sciences · 2021Review
- Alginate nanogels-based thermosensitive hydrogel to improve antidepressant-like effects of albiflorin via intranasal delivery.Drug delivery · 2021Article
- Reduced plasma Fetuin-A is a promising biomarker of depression in the elderly.European archives of psychiatry and clinical neuroscience · 2020Article
- The role of trauma experiences, personality traits, and genotype in maintaining posttraumatic stress disorder symptoms among child survivors of the Wenchuan earthquake.BMC psychiatry · 2020Article
- The Contribution of Rat Studies to Current Knowledge of Major Depressive Disorder: Results From Citation Analysis.Frontiers in psychology · 2020Article
- Chronic Food Antigen-specific IgG-mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder.Genomics, proteomics & bioinformatics · 2019Article
- NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway.Mediators of inflammation · 2019Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Responses of the hypothalamic-pituitary-adrenal axis (HPAA), immune system and metabolic pathways are involved in adaptation to stress, while alterations in these responses have been implicated in the development of major depressive disorder (MDD). Multiple laboratory indices are known to react in response to the acute stress, however, no valid biomarkers have been reported, which can differentiate stress response in depressed individuals. The aim of this study was to assess changes in a set of laboratory parameters in patients with MDD in response to a moderate mental stress and to find potential markers of altered stress reactivity associated with depression. A group of 33 MDD patients and 43 control subjects underwent clinical evaluation to assess depression and anxiety symptoms, as well as heart rate variability (HRV) analysis. Participants were asked to perform a time constrained cognitive task, and selected hormones (cortisol, ACTH), cytokines (IL-6, IL-1β, TNF-α), neurotrophic factors (BDNF, CNTF) and metabolic parameters (glucose, cholesterol, triglycerides) were measured before and 60 min after the task performance. HRV analysis showed increased sympathetic input in MDD patients. The MDD group manifested an elevated HPAA activity as well as IL-6 and CNTF levels at baseline. A specific stress-induced increase in glucose and TNF-α was revealed in the MDD group, which was absent in control subjects. The data confirm the impairments of stress response in MDD and suggest that the reaction of simple metabolic and pro-inflammatory indices to a mild stressogenic challenge may be indicative of a depressive state.
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