Trial reportClinical research in cardiology : official journal of the German Cardiac Society2019
Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Thrombolytic therapy for pulmonary embolism.The Cochrane database of systematic reviews · 2021Pooled it
- Trial
- Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Trial
- One-Year Echocardiographic, Functional, and Quality of Life Outcomes After Ultrasound-Facilitated Catheter-Based Fibrinolysis for Pulmonary Embolism.Circulation. Cardiovascular interventions · 2020Trial
- Chronic thromboembolism phenotypes after acute pulmonary embolism: identification with the SEARCH algorithm.The European respiratory journal · 2026Observational
- Artificial Intelligence-Enhanced Electrocardiogram for Longitudinal Evaluation of Right Ventricular Dysfunction After Acute Pulmonary Embolism: Rational and Design of CURES-CARE Study.Pulmonary circulation · 2026Article
- Post-Pulmonary Embolism Syndrome: New Phenotypes Come into Focus.Journal of clinical medicine · 2026Review
- Beyond Baseline: Dynamic Prognostic Assessment in Acute Pulmonary Embolism.Arquivos brasileiros de cardiologia · 2026Article
- A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism.Scientific reports · 2025Article
- Comparison of half-dose alteplase and LMWH in intermediate-high risk pulmonary embolism: a single-center observational study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Article
- Article
- Endovascular management of intermediate-risk pulmonary embolism: evidence, outstanding questions, drivers of utilization, and the horizon.European heart journal open · 2025Review
- Efficacy and Safety of Systemic Thrombolysis and Catheter-Directed Therapy in Pulmonary Embolism: A Narrative Review.Cureus · 2024Review
- Catheter Interventions for Pulmonary Embolism: Mechanical Thrombectomy Versus Thrombolytics.Methodist DeBakey cardiovascular journal · 2024Review
- Observational cohort study to validate SEARCH, a novel hierarchical algorithm to define long-term outcomes after pulmonary embolism.BMJ open · 2023Observational
- Prevalence of long-term right ventricular dysfunction after acute pulmonary embolism: a systematic review and meta-analysis.EClinicalMedicine · 2023Article
- Right ventricular functional recovery assessment with stress echocardiography and cardiopulmonary exercise testing after pulmonary embolism: a pilot prospective multicentre study.BMJ open respiratory research · 2023Article
- Echocardiographic predictors of mortality in intermediate-risk pulmonary embolism.Internal and emergency medicine · 2022Article
- Evolving Management Trends and Outcomes in Catheter Management of Acute Pulmonary Embolism.Journal of cardiothoracic and vascular anesthesia · 2022Review
- Joint Guideline on Venous Thromboembolism - 2022.Arquivos brasileiros de cardiologia · 2022Article
Corrections and comments
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Authors and funding
31 authors at 20 institutions in 10 countries.
Funding
Abstract
introductionSymptoms and functional limitation are frequently reported by survivors of acute pulmonary embolism (PE). However, current guidelines provide no specific recommendations on which patients should be followed after acute PE, when follow-up should be performed, and which tests it should include. Definition and classification of late PE sequelae are evolving, and their predictors remain to be determined.
methodsIn a post hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial, we focused on 219 survivors of acute intermediate-risk PE with clinical and echocardiographic follow-up 6 months after randomisation as well as over the long term (median, 3 years after acute PE). The primary outcome was a composite of (1) confirmed chronic thromboembolic pulmonary hypertension (CTEPH) or (2) 'post-PE impairment' (PPEI), defined by echocardiographic findings indicating an intermediate or high probability of pulmonary hypertension along with New York Heart Association functional class II-IV.
resultsConfirmed CTEPH or PPEI occurred in 29 (13.2%) patients, (6 with CTEPH and 23 with PPEI). A history of chronic heart failure at baseline and incomplete or absent recovery of echocardiographic parameters at 6 months predicted CTEPH or PPEI at long-term follow-up.
conclusionsCTEPH or PPEI occurs in almost one out of seven patients after acute intermediate-risk PE. Six-month echocardiographic follow-up may be useful for timely detection of late sequelae.
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