ArticleMikrochimica acta2018
Determination of alkaline phosphatase activity and of carcinoembryonic antigen by using a multicolor liquid crystal biosensor based on the controlled growth of silver nanoparticles.
Article in Mikrochimica acta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Liquid Crystal Biosensors: Principles, Structure and Applications.Biosensors · 2022Review
- State-of-the-Art Development in Liquid Crystal Biochemical Sensors.Biosensors · 2022Review
- Cysteine-assisted photoelectrochemical immunoassay for the carcinoembryonic antigen by using an ITO electrode modified with CMikrochimica acta · 2019Article
- MnOMikrochimica acta · 2019Article
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Authors and funding
5 authors.
Funding
Abstract
An ultrasensitive liquid crystal biosensor is described for multicolor visualization of the activity of alkaline phosphatase (ALP) based on the controlled growth of silver nanoparticles. The enzymatic product is accumulated on the surface of the LC sensing film by means of silver deposition, and the birefringent signal (observed with a polarizing microscope) is strongly enhanced as a result. The presence of AuNPs also enhances the sensitivity by about 4 orders of magnitude. The bright spots in polarized optical microscopy (POM) images increase with increasing activities of ALP. The signal intensities of the spots are then calculated by using Photoshop software and by multiplying the average brightness of the spots by the pixel value. The detection limit for ALP is 1.2 nU·mL
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