ArticleEuropean journal of applied physiology2019
Comparison between men and women of volume regulating hormones and aquaporin-2 excretion following graded central hypovolemia.
Article in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Optic nerve sheath diameter increases during 12Frontiers in physiology · 2026Article
- Internal jugular venous flow responses to graded lower body negative pressure: a sex-stratified analysis.Frontiers in physiology · 2026Article
- Dose-dependent reduction of optic nerve sheath diameter during graded lower body negative pressure in healthy adults of both sexes.Frontiers in network physiology · 2026Article
- Repeatability of artificial gravity tolerance times.Frontiers in physiology · 2025Article
- Article
- Compensatory hemodynamic changes in response to central hypovolemia in humans: lower body negative pressure: updates and perspectives.Journal of muscle research and cell motility · 2023Review
- Early Biomarkers of Altered Renal Function and Orthostatic Intolerance During 10-day Bedrest.Frontiers in physiology · 2022Article
- Diagnosing Neurally Mediated Syncope Using Classification Techniques.Journal of clinical medicine · 2021Article
- Seasonal rhythms of vasopressin release and aquaporin-2 excretion assure appropriate water conservation in humans.Journal of translational medicine · 2021Article
- Rapid development of vasopressin resistance in dietary KAmerican journal of physiology. Renal physiology · 2021Article
- Enhanced Blood Supply Through Lower Body Negative Pressure During Slow-Paced, High Load Leg Press Exercise Alters the Response of Muscle AMPK and Circulating Angiogenic Factors.Frontiers in physiology · 2020Article
- Galanin and Adrenomedullin Plasma Responses During Artificial Gravity on a Human Short-Arm Centrifuge.Frontiers in physiology · 2018Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Central hypovolemia induced by orthostatic loading causes reno-vascular changes that can lead to orthostatic intolerance. In this study, we investigated volume regulating hormonal responses and reno-vascular changes in male and female subjects as they underwent central hypovolemia, induced by graded lower body negative pressure (LBNP). Aquaporin-2 (AQP2) excretion was measured as a biomarker for the renal system response to vasopressin. 37 young healthy subjects (n = 19 males; n = 18 females) were subjected to graded LBNP until - 40 mmHg LBNP. Under resting conditions, males had significantly higher copeptin (a stable peptide derived from vasopressin) levels compared with females. Adrenocorticotropin (ACTH), adrenomedullin (ADM), vasopressin (AVP) and brain natriuretic peptide (BNP) were not affected by our experimental protocol. Nevertheless, an analysis of ADM and BNP with the data normalized as percentages of the baseline value data showed an increase from baseline to 10 min after recovery in the males in ADM and in the females in BNP. Analysis of BNP and ADM raises the possibility of a preferential adaptive vascular response to central hypovolemia in males as shown by the normalized increase in ADM, whereas females showed a preferential renal response as shown by the normalized increase in BNP. Furthermore, our results suggest that there might be a difference between men and women in the copeptin response to alterations in orthostatic loading, simulated either using LBNP or during posture changes.
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